تأثير حقن عقار الديتوميدين على بعض الفحوصات الكيموحيوية في الخيول

Abstract EN

The study was designed to evaluate the effect of detomidine on blood chemistry and electrolyte profile in horses.

Six horses were injected intravenously with detomidine in a dose of (0.02 mg/kg B.W).

Blood samples were collected before drug administration and at 5,15,30,60,120 minutes and 24 hours post injection.

Results were revealed a significant increase (p≤ 0.05) in the level of (ALP) enzyme at 30,60,120 minutes after injection, and a modest non-significant increase of (ALT) and (SDH) enzymes at15,30,60 minutes after drug injection.

A significant increase in the level of (CPK) enzyme at 30,60,120 minutes was seen and a significant increase in the level of (AST) enzyme has occurred at 15,30,60 minutes.

The calcium was gain a slight non-significant increase at 60, and 120 minutes after injection, while the sodium was gain a significant increase at 30,60,120 minutes after the injection, where there was a significant noticeable rise in blood glucose at 15,30,60,120 minutes after injection.

In conclusion the detomidine has an effect on blood biochemistry, and it was safe sedative and analgesic drug which can be used to make some simple surgical interventions.