Embryonic markers association in mice bearing mammary adenocarcinoma (AN3) transplantable tumor model
Other Title(s)
المعلمات الجنينة المصاحبة لأورام الغدة اللبنية المغروسة في الفئران لخط AN3
Joint Authors
Salman, Marwah Ibrahim
al-Mzain, Aws Qahtan
Ulwan, Layth Husayn
al-Atabi, Murad
Ajil, Adnan Khazal
Khalid, Asil
Duwish, Ahlam
al-Rikabi, Nahi Yusuf Yasin
al-Shammari, Ahmad Majid Hamzah
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 8, Issue 2 (31 Dec. 2015), pp.152-156, 5 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
AN3 tumor model had special importance as breast cancer model to evaluate new and novel therapeutic agents and there is need to study the tumor associated markers presence during AN3 tumor growth.
Most common markers are Carcinoembryonic antigen (CEA) and α- fetoprotein (AFP) which are cells surface glycoproteins.
Oncofetal antigens involved in cell adhesion marker for cancers diagnosis and prognosis and normally they are not present in the blood of healthy adults.
AN3 is transplantable mammary adenocarcinoma tumor used as in vivo model for years in cancer research for human breast cancer.
Hence studying the presence of associated tumor antigens that extensively used as tumor markers (AFP and CEA) is necessary to characterize the model and determine the usefulness to use them as follow up markers after testing therapeutic agents in this model.
Healthy and pregnant healthy female mice were used as control groups and AN3 transplanted mice measured after tumor grow to reach at least 0.5 cm.
The results showed that CEA is markedly high in mice bearing tumors while no presence of it in both control groups.
AFP had a different picture as the higher percentage was in the pregnant females, which is very normal because AFP is a fetal protein, but mice bearing tumor significantly higher concentration than healthy mice.
In conclusion, AFP and CEA are useful markers to be used for AN3 model in experimental evaluation of novel therapies follow up.
American Psychological Association (APA)
al-Shammari, Ahmad Majid Hamzah& Salman, Marwah Ibrahim& al-Mzain, Aws Qahtan& Ulwan, Layth Husayn& Ajil, Adnan Khazal& al-Atabi, Murad…[et al.]. 2015. Embryonic markers association in mice bearing mammary adenocarcinoma (AN3) transplantable tumor model. Iraqi Journal of Cancer and Medical Genetics،Vol. 8, no. 2, pp.152-156.
https://search.emarefa.net/detail/BIM-819433
Modern Language Association (MLA)
al-Shammari, Ahmad Majid Hamzah…[et al.]. Embryonic markers association in mice bearing mammary adenocarcinoma (AN3) transplantable tumor model. Iraqi Journal of Cancer and Medical Genetics Vol. 8, no. 2 (2015), pp.152-156.
https://search.emarefa.net/detail/BIM-819433
American Medical Association (AMA)
al-Shammari, Ahmad Majid Hamzah& Salman, Marwah Ibrahim& al-Mzain, Aws Qahtan& Ulwan, Layth Husayn& Ajil, Adnan Khazal& al-Atabi, Murad…[et al.]. Embryonic markers association in mice bearing mammary adenocarcinoma (AN3) transplantable tumor model. Iraqi Journal of Cancer and Medical Genetics. 2015. Vol. 8, no. 2, pp.152-156.
https://search.emarefa.net/detail/BIM-819433
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-819433