Effects of therapeutic lifestyle change diet and Q10 plus L-carnitine supplementation on inflammatory biomarkers of in-stent restenosis, lipid profile, and left ventricular ejection fraction in myocardial infarction : a randomized clinical trial
Joint Authors
Iftikhari, Muhammad Hassan
Sharifi, Muhammad Husayn
Ostovan, Muhammad Ali
Rezaianzadeh, Abbas
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 19, Issue 4 (30 Apr. 2017), pp.1-11, 11 p.
Publisher
Publication Date
2017-04-30
Country of Publication
United Arab Emirates
No. of Pages
11
Main Subjects
Abstract EN
Background: Following Myocardial Infarction (MI) and percutaneous coronary intervention (PCI), the modification of cardiovascular risk factors and inflammation can improve MI progression and PCI outcomes.
Up to now, no certain conclusions have been drawnregarding the effect of therapeutic lifestyle change (TLC) diet and a combination of Q10 plus L-carnitine (LC) supplementation on inflammatory biomarkers of In-Stent Restenosis (ISR), lipid profile, and Left ventricular ejection fraction (LVEF).
Objectives: This study aimed to evaluate the effects of TLC diet and Q10 plus LC supplementation on inflammatory biomarkers of ISR, lipid profile, and LVEF following MI and PCI.
Methods: This single-blind randomized controlled trial was conducted on 128 subjects.
After randomization for treatment allocation, the subjects were divided into the study groups through block randomization.
The MI patients were admitted to 2 hospitals, namely Al-Zahra and Kowsar (Shiraz, Iran), between April 2015 and May 2016.
The patients were divided into 4 groups receiving TLC diet (A), oral Q10 150 mg/d and LC 1200 mg/d (B), a combination of LC plus Q10 and TLC diet (C), and the routine care (D).
This study evaluated Interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP) as inflammatory biomarkers of ISR, lipid profile, and LVEF in 128 patients with MI undergoing PCI before and 3 months after the intervention.
Results: The results showed a significant decrease in hs-CRP in groups B (11.84.3 to 2.01 mg/L) and C (11.73.9 to 1.31.1 mg/L) (P < 0.0001 and P < 0.0001, respectively), but not in group A.
Also, a significant reduction was found in IL-6 in groups A (38.015 to 9.4 2 pg/mL), B (34.612 to 5.12.4 pg/mL), and C (33.712 to 4.82.1 pg/mL) (P < 0.0001, P < 0.0001, and P < 0.0001, respectively).
Additionally, LDL and total cholesterol, but not TG, levels significantly decreased in groups A (150 17 to 80 13 mg/dL), B (148 15 to 77.2 14 mg/dL), and C (142 11 to 64.8 10 mg/dL) (P < 0.0001, P < 0.001, and P < 0.0001, respectively).
Nevertheless, only group C showed a significant improvement in LVEF (45.18 to 53.68) (P < 0.027).
Conclusions: An adjuvant therapy with TLC diet and supplementation with Q10 and LC seems to be required for secondary prevention following MI and PCI.
TLC diet and Q10 plus LC appeared to be effective in inflammatory biomarkers of ISR as well as LDL reduction.
American Psychological Association (APA)
Sharifi, Muhammad Husayn& Iftikhari, Muhammad Hassan& Ostovan, Muhammad Ali& Rezaianzadeh, Abbas. 2017. Effects of therapeutic lifestyle change diet and Q10 plus L-carnitine supplementation on inflammatory biomarkers of in-stent restenosis, lipid profile, and left ventricular ejection fraction in myocardial infarction : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 4, pp.1-11.
https://search.emarefa.net/detail/BIM-820692
Modern Language Association (MLA)
Sharifi, Muhammad Husayn…[et al.]. Effects of therapeutic lifestyle change diet and Q10 plus L-carnitine supplementation on inflammatory biomarkers of in-stent restenosis, lipid profile, and left ventricular ejection fraction in myocardial infarction : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 19, no. 4 (Apr. 2017), pp.1-11.
https://search.emarefa.net/detail/BIM-820692
American Medical Association (AMA)
Sharifi, Muhammad Husayn& Iftikhari, Muhammad Hassan& Ostovan, Muhammad Ali& Rezaianzadeh, Abbas. Effects of therapeutic lifestyle change diet and Q10 plus L-carnitine supplementation on inflammatory biomarkers of in-stent restenosis, lipid profile, and left ventricular ejection fraction in myocardial infarction : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 4, pp.1-11.
https://search.emarefa.net/detail/BIM-820692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-11
Record ID
BIM-820692