تحضير مضغوطات طافية مطولة التأثير للميترونيدازول
Other Title(s)
Preparing floating and prolonged release of metronidazole tablets
Joint Authors
Source
المجلة العربية للعلوم الصيدلية
Issue
Vol. 5, Issue 1 (31 May. 2014), pp.21-31, 11 p.
Publisher
Publication Date
2014-05-31
Country of Publication
Syria
No. of Pages
11
Main Subjects
Abstract EN
The purpose of this study was to prepare floating and prolonged release tablets of metronidazole, those tablets were developed to prolong the gastric residence time that helps to achieve a better eradication of Helicobacter Pylori.
Hydroxy Propyl Methyl Cellulose (HPMC K4M) was used as floating polymer and combined with other polymers like HPMC 15LV and HPMC K100M, and sodium bicarbonate and citric acid as effervescent agents.
The prepared formulations were evaluated in terms their precompression parameters, physical characteristics, floating properties, dissolution test and in vitro drug release kinetic studies.
The results showed that the combination between HPMC K4M and HPMC K100M was the best for preparing floating and prolonged release tablets of metronidazole as in formulation (F6) which had floated for more than 24 hours and released about 98% from its content within 22 hours and its release kinetic was Korsmeyre-Peppas
American Psychological Association (APA)
الجمعة، هديل وتميم حماد. 2014. تحضير مضغوطات طافية مطولة التأثير للميترونيدازول. المجلة العربية للعلوم الصيدلية،مج. 5، ع. 1، ص ص. 21-31.
https://search.emarefa.net/detail/BIM-830512
Modern Language Association (MLA)
الجمعة، هديل وتميم حماد. تحضير مضغوطات طافية مطولة التأثير للميترونيدازول. المجلة العربية للعلوم الصيدلية مج. 5، ع. 1 (أيار 2014)، ص ص. 21-31.
https://search.emarefa.net/detail/BIM-830512
American Medical Association (AMA)
الجمعة، هديل وتميم حماد. تحضير مضغوطات طافية مطولة التأثير للميترونيدازول. المجلة العربية للعلوم الصيدلية. 2014. مج. 5، ع. 1، ص ص. 21-31.
https://search.emarefa.net/detail/BIM-830512
Data Type
Journal Articles
Language
Arabic
Notes
Record ID
BIM-830512