Synthesis of new 1, 2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro
Other Title(s)
تحضير استرات الفلوروكوينولون ذات التأثير المضاد للسرطان في الزجاج
Joint Authors
Said, Banan Burhan
al-Iraqi, Muhammad Ahmad
al-Abaji, Faris Dhannun
Source
المجلة العراقية للعلوم البيطرية
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
English Abstract
Three 1,2 dithiole 3-thion fluoroquinolone esters (2-4) were prepared via condensation of (p-hydroxyl phenyl) -1,2dithiole- 3-thione with fluoroquinolones (Ciprofloxacin, Gatefloxacin and Moxifloxacin).
The biological activity of these compounds was assayed against 60 types of cancer cells in vitro.
The compound 2 (NSC=760553) showed anticancer activity against renal cell, while the comound 4 (NSC=760555) show activity against three types of cancer cell.
The expected mechanism of their activity is that 1,2dithiole 3-thione derivatives may give H2S as new gas transmitter which play an important role in the biological systems.
Data Type
Conference Papers
Record ID
BIM-831032
American Psychological Association (APA)
Said, Banan Burhan& al-Iraqi, Muhammad Ahmad& al-Abaji, Faris Dhannun. 2012-12-31. Synthesis of new 1, 2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. Scientific Conference College of Veterinary Medicine (Clinical and Applied Veterinary) (6th : 2012 : University of Mosul, Iraq). . Vol. 26, Fourth supplement (2012), pp.115-121.Mosul Iraq : University of Mosul College of Veterinary Medicine.
https://search.emarefa.net/detail/BIM-831032
Modern Language Association (MLA)
Said, Banan Burhan…[et al.]. Synthesis of new 1, 2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. . Mosul Iraq : University of Mosul College of Veterinary Medicine. 2012-12-31.
https://search.emarefa.net/detail/BIM-831032
American Medical Association (AMA)
Said, Banan Burhan& al-Iraqi, Muhammad Ahmad& al-Abaji, Faris Dhannun. Synthesis of new 1, 2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro. . Scientific Conference College of Veterinary Medicine (Clinical and Applied Veterinary) (6th : 2012 : University of Mosul, Iraq).
https://search.emarefa.net/detail/BIM-831032
