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Evaluation of MC4R (rs17782313, rs17700633), AGRP (rs3412352) and POMC (rs1042571) polymorphisms with obesity in northern India
Joint Authors
Mittal, Balraj
Srivastava, Apurva
Srivastava, Neena
Narain, Varun Shanker
Natu, S. M.
Prakash, Jai
Source
Issue
Vol. 29, Issue 2 (30 Apr. 2014), pp.114-118, 5 p.
Publisher
Publication Date
2014-04-30
Country of Publication
Oman
No. of Pages
5
Main Subjects
Abstract EN
Objective: Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity.
Therefore, the aim of this study is to examine MC4R rs17782313, MC4R rs17700633, AGRP rs3412352 and POMCrs1042571 for any association with obesity in North Indian subjects.
Methods: The variants were investigated for association in 300 individuals with BMI ≥30 kg/m2 and 300 healthy non-obese individuals BMI <30 kg/m2.
The genotyping were analyzed by Taqman probes.
The statistical analysis was performed by the SPSS software, ver.19 and p≤0.05 was considered statistically significant.
Results: The genotypes of MC4R rs17782313 and POMC rs1042571 were significantly associated with obesity (C), (p=0.02; OR=1.7 and p=0.01; OR=1.6, respectively); however, MC4Rrs17700633 (p=0.001; OR=0.55) was associated with low risk.
In addition, AGRPrs3412352 (p=0.93; OR=0.96) showed no association with obesity (BMI ≥30 kg/m2) in North Indian subjects.
Conclusion: This study provides the report about the significant association of MC4R (rs17782313) and POMC (rs1042571) with morbid obesity (BMI ≥30 kg/m2), but MC4R (rs17700633) and AGRP (rs34123523) did not show any association with obesity in the studied North Indian population
American Psychological Association (APA)
Srivastava, Apurva& Mittal, Balraj& Prakash, Jai& Narain, Varun Shanker& Natu, S. M.& Srivastava, Neena. 2014. Evaluation of MC4R (rs17782313, rs17700633), AGRP (rs3412352) and POMC (rs1042571) polymorphisms with obesity in northern India. Oman Medical Journal،Vol. 29, no. 2, pp.114-118.
https://search.emarefa.net/detail/BIM-831745
Modern Language Association (MLA)
Mittal, Balraj…[et al.]. Evaluation of MC4R (rs17782313, rs17700633), AGRP (rs3412352) and POMC (rs1042571) polymorphisms with obesity in northern India. Oman Medical Journal Vol. 29, no. 2 (2014), pp.114-118.
https://search.emarefa.net/detail/BIM-831745
American Medical Association (AMA)
Srivastava, Apurva& Mittal, Balraj& Prakash, Jai& Narain, Varun Shanker& Natu, S. M.& Srivastava, Neena. Evaluation of MC4R (rs17782313, rs17700633), AGRP (rs3412352) and POMC (rs1042571) polymorphisms with obesity in northern India. Oman Medical Journal. 2014. Vol. 29, no. 2, pp.114-118.
https://search.emarefa.net/detail/BIM-831745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 117-118
Record ID
BIM-831745