Linear growth arrest without weight gain due to overuse of topical clobetasol
Joint Authors
Razavi, Zahrah
Sanginabadi, Milad
Source
Issue
Vol. 29, Issue 6 (31 Dec. 2014), pp.454-457, 4 p.
Publisher
Publication Date
2014-12-31
Country of Publication
Oman
No. of Pages
4
Main Subjects
Abstract EN
Prolonged potent topical glucocorticoid therapy in infants can cause iatrogenic Cushing’s syndrome.
This case highlights the rarity of poor weight gain in iatrogenic Cushing’s syndrome.
A 17-month-old boy was referred to outpatients pediatric endocrine clinic for evaluation of growth failure.
On presentation his weight was 9.7kg (5th percentile) and height was 72cm (-3.6 SD below mean for age and sex).
Systemic examination revealed grossly moon-like face, hypertrichosis and thin skin in the genital area.
His mother reported using local clobetasol for the previous seven months for his diaper dermatitis.
Baseline plasma cortisol was low (0.3ng/ml, normal range: 60 to 280ng/ml).
During standard dose of synthetic adrenocorticotropic hormone test, the peak cortisol level was 0.4ng/ml (N>180ng/ml) and was consistent with hypothalamic–pituitary–adrenal axis suppression.
The patient’s clinical presentation and laboratory investigations confirmed the diagnosis of secondary adrenal insufficiency and iatrogenic Cushing’s syndrome.
He was treated successfully by discontinuing use of clobetasol.
His appearance and growth returned to normal within two months.
Morning cortisol was 101.2ng/ml after stopping the oral physiologic dose of hydrocortisone.
Our case differed from other reports of iatrogenic Cushing’s syndrome by presenting in poor weight gain rather than obesity.
American Psychological Association (APA)
Razavi, Zahrah& Sanginabadi, Milad. 2014. Linear growth arrest without weight gain due to overuse of topical clobetasol. Oman Medical Journal،Vol. 29, no. 6, pp.454-457.
https://search.emarefa.net/detail/BIM-831875
Modern Language Association (MLA)
Razavi, Zahrah& Sanginabadi, Milad. Linear growth arrest without weight gain due to overuse of topical clobetasol. Oman Medical Journal Vol. 29, no. 6 (2014), pp.454-457.
https://search.emarefa.net/detail/BIM-831875
American Medical Association (AMA)
Razavi, Zahrah& Sanginabadi, Milad. Linear growth arrest without weight gain due to overuse of topical clobetasol. Oman Medical Journal. 2014. Vol. 29, no. 6, pp.454-457.
https://search.emarefa.net/detail/BIM-831875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 456-457
Record ID
BIM-831875