Synthesis and spectroscopic study of 1, 2-thiazine system incorporating various ester groups

Abstract EN

A series of 3-substituted-methyl-1,2-thiazines (4 a-g) was exclusively obtained in high yields for the first time through nucleophilic substitution reaction of 4,6-dibromo-2- phenyl-5-methyl-3-bromomethyl-1,1-dioxo-1,2-thiazines (3) with each of sodium Formate, acetate, propanoate, glycinate, benzoate, glycolate and salicylate as nucleophilic reagents in a highly polar aprotic solvent at room temperature.

The IR, 1H- and 13C-NMR and MS spectra of the prepared compounds were conformed to their proposed structures