Evaluation of anti-phospholipid antibodies in young patients with thromboembolic stroke

Other Title(s)

تقييم ضد الفوسفوليد في المرضى الشباب الذين يعانون من السكتة الدماغية

Joint Authors

Kashmulah, Muna A.
Isa, Muhammad M. A.
Hazza, Salman Isa

Source

Duhok Medical Journal

Publisher

University of Duhok College of Medicine

Publication Date

2012-12-31

Country of Publication

Iraq

No. of Pages

8

Main Subjects

Pharmacy, Health & Medical Sciences

English Abstract

Background and objective: To evaluate the antiphospholipid antibodies in young patients with thromboembloic stroke and to define the types and effective isotypes of some important antiphospholipids which are lupus anticoagulant, anticardiolipin and antiphosphatidyle serine antibodies, also to find any concomitant effect of some non antiphospholipid parameters.

Methods: A case control study performed in Ibn-Sina and Al-Salam Teaching Hospitals.

Seventy five young patients (age less than 45 years) with thromboembolic stroke diagnosed by magnetic resonance imaging and without any clear recognizable factors.

Detection of antiphospholipid antibodies was done for lupus anticoagulant and assay of anticardiolipin and antiphosphatidyl serine antibodies by enzyme linked immunoassay.

Anti-nuclear antibodies, C-reactive protein and D-Dimer reaction were tested by immunoserological methods.

Fifty healthy, age and sex matched blood donors as healthy volunteers were studied as control group.

Results: The detected cases with positive antibodies formed(26.7%),and the mean age was 32±12 year and male to female ratio 2:3.

Lupus anticoagulant was positive in 8% of cases.

Moderately and highly positive anticardiollipin antibodies (IgG and IgM) level were significantly more seen in patients with stroke than the control with P(<0.001) for each type of antibodies.

Moderately and highly positive antiphosphatidyl serine antibodies (IgG and IgM) levels were significantly more seen in patients with stroke than the control with P value <0.001 for each type of antibodies.

Low positive level for both anticardiolipin and antiphosphatidyl serine antibodies were of no value in young patients with thromboembolic stroke.

High CRP level was of significant in young patients with thromboembolic stroke and positive antiphospholipid (P<0.05) .

Positive D-dimer reaction was seen in positive antiphospholipid patients P(<0.001).

Conclusion: Moderately and highly positive antiphospholipid antibodies were shown to play an important role in the development of thromboembolic stroke in young patients less than 45 years.

Data Type

Conference Papers

Record ID

BIM-832184

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