Increased transforming growth factor-ß and interleukin-17 transcripts in peripheral blood of breast cancer patients with different clinical stages
Joint Authors
Touma, Hadil Salim
Shani, Wafa Sadun
Source
Issue
Vol. 15, Issue 2 (30 Jun. 2018), pp.145-149, 5 p.
Publisher
University of Babylon College of Medicine
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Background: Currently, cancer as major problem around the world threatens human health and has a high incidence in developing countries.
Many reports have showed that there is a dysfunction in the immune system of cancer patients.
Interleukin-17 (IL-17) and transforming growth factor (TGF--) are increased in the generated through cancers, and IL-17 is considered as a pro-inflammatory cytokine; IL-17 is an angiogenic factor and promotes tumor growth.
Materials and Methods: In this study TGF and IL-17, mRNA gene expression has been measured in peripheral blood of 35 breast cancer patients and 35 normal age-matched women using quantitative real-time polymerase chain reaction method with master mix reaction containing SYBER Green.
actin gene was used as housekeeping gene.
Results: Our data demonstrated a significant upregulation of TGFand IL-17 gene expression (P-0.05) in patient’s peripheral blood compared to normal healthy control.
Levels of genes expression were higher in the breast cancer group compared to the control group.
Conclusion: TGFand IL-17 expression could be used as a diagnostic marker for detecting breast cancer.
American Psychological Association (APA)
Touma, Hadil Salim& Shani, Wafa Sadun. 2018. Increased transforming growth factor-ß and interleukin-17 transcripts in peripheral blood of breast cancer patients with different clinical stages. Medical Journal of Babylon،Vol. 15, no. 2, pp.145-149.
https://search.emarefa.net/detail/BIM-832261
Modern Language Association (MLA)
Touma, Hadil Salim& Shani, Wafa Sadun. Increased transforming growth factor-ß and interleukin-17 transcripts in peripheral blood of breast cancer patients with different clinical stages. Medical Journal of Babylon Vol. 15, no. 2 (Apr. / Jun. 2018), pp.145-149.
https://search.emarefa.net/detail/BIM-832261
American Medical Association (AMA)
Touma, Hadil Salim& Shani, Wafa Sadun. Increased transforming growth factor-ß and interleukin-17 transcripts in peripheral blood of breast cancer patients with different clinical stages. Medical Journal of Babylon. 2018. Vol. 15, no. 2, pp.145-149.
https://search.emarefa.net/detail/BIM-832261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 149
Record ID
BIM-832261