New animal model of induced acute hepatic injury by acetaminophen and vitamin D3 protective effect
Author
Source
Issue
Vol. 15, Issue 1 (31 Mar. 2018), pp.28-31, 4 p.
Publisher
University of Babylon College of Medicine
Publication Date
2018-03-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Abstract EN
Background : Drug-induced liver injury is of great interest especially drugs that broadly used like acetaminophen.
Objective : To assess new model of acetaminophen-induced acute hepatic injury and Vitamin D3 effectiveness.
Materials and Methods : Eighteen male rabbits allocated into three groups six rabbits for each.
Group 1 receives acetaminophen to induce acute hepatic injury and Group 2 receive single injection of Vitamin D3 before induction of hepatic injury, and group 3 was control.
After 24 h from three-spaced injection of acetaminophen sample of blood taken to measure serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, and albumin.
Results : Successful model of acetaminophen-induced hepatic injury achieved by significant elevation (P ≤ 0.05) of ALT and AST of Group 1 and 2 compared with control.
No significance variation observed (P ≥ 0.05) between treatment Group 1 and 2 in liver function enzymes level.
Conclusion : A new easy model of acetaminophen-induced acute hepatic injury effectively obtained.
Although no statistical signifi cant Vitamin D3 lower the levels of ALT and AST.
American Psychological Association (APA)
al-Sadi, Malath Aziz. 2018. New animal model of induced acute hepatic injury by acetaminophen and vitamin D3 protective effect. Medical Journal of Babylon،Vol. 15, no. 1, pp.28-31.
https://search.emarefa.net/detail/BIM-832319
Modern Language Association (MLA)
al-Sadi, Malath Aziz. New animal model of induced acute hepatic injury by acetaminophen and vitamin D3 protective effect. Medical Journal of Babylon Vol. 15, no. 1 (Jan. / Mar. 2018), pp.28-31.
https://search.emarefa.net/detail/BIM-832319
American Medical Association (AMA)
al-Sadi, Malath Aziz. New animal model of induced acute hepatic injury by acetaminophen and vitamin D3 protective effect. Medical Journal of Babylon. 2018. Vol. 15, no. 1, pp.28-31.
https://search.emarefa.net/detail/BIM-832319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 30-31
Record ID
BIM-832319