New animal model of induced acute hepatic injury by acetaminophen and vitamin D3 protective effect

Abstract EN

Background : Drug-induced liver injury is of great interest especially drugs that broadly used like acetaminophen.

Objective : To assess new model of acetaminophen-induced acute hepatic injury and Vitamin D3 effectiveness.

Materials and Methods : Eighteen male rabbits allocated into three groups six rabbits for each.

Group 1 receives acetaminophen to induce acute hepatic injury and Group 2 receive single injection of Vitamin D3 before induction of hepatic injury, and group 3 was control.

After 24 h from three-spaced injection of acetaminophen sample of blood taken to measure serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, and albumin.

Results : Successful model of acetaminophen-induced hepatic injury achieved by significant elevation (P ≤ 0.05) of ALT and AST of Group 1 and 2 compared with control.

No significance variation observed (P ≥ 0.05) between treatment Group 1 and 2 in liver function enzymes level.

Conclusion : A new easy model of acetaminophen-induced acute hepatic injury effectively obtained.

Although no statistical signifi cant Vitamin D3 lower the levels of ALT and AST.