The effect of zinc supplementation on disease activity in patients with rheumatoid arthritis

Other Title(s)

تأثير مكملات الزنك على نشاط المرض في المرضى الذين يعانون من التهاب المفاصل الروماتويدي

Joint Authors

Rasul, Muhammad T.
Sulayman, Diya M.
al-Tamimi, Diya J.

Source

Duhok Medical Journal

Publisher

University of Duhok College of Medicine

Publication Date

2012-12-31

Country of Publication

Iraq

No. of Pages

10

Main Subjects

Pharmacy, Health & Medical Sciences

English Abstract

Background and objectives The levels of micronutrient especially zinc is significantly deteriorated in rheumatoid arthritis(RA), which in turn results in vicious cycle of damage and various grade of high Disease Activity Score derivative for 28 joints (DAS-28) in RA patients .

The objective was to evaluate the effects of zinc supplementations on zinc status and disease activity in RA patients.

Methods: Ninety four patients (88 females and 6 males) participated in 6-months, intervention study.

Baseline zinc status and biological markers of disease activity were measured and compared to that of 94 apparently healthy control subjects.

Patients were assigned to receive 50 mg elemental zinc three times a day for six months period, as a complementary to their conventional drugs.

Disease activity was assessed after intervention using the DAS-28.

Results: Significant change from baseline in DAS-28 was noted; high DAS-28 was seen in 25 patients (26.6%) after supplementation with zinc in contrast to 72 patients (76.6%) at the beginning of the study(p<0.01) .Eight patients on zinc supplementation showed remission of disease (8.5%).

Conclusions: This study indicates that zinc supplementation play an important role in decreasing disease activity in these patients.

Data Type

Conference Papers

Record ID

BIM-832343

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