Developing and characterization of nonionic microemulsions containing ferrous sulfate and folic acid for transdermal application
Other Title(s)
تطوير و تحديد خواص مستحلبات دقيقة ذات عوامل فعالة على السطح غير متأينة تحوي سلفات الحديد مع حمض الفوليك بغرض التطبيق عبر الجلد
Dissertant
al-Ghatm, Husayn Yusuf Abd Allah
Thesis advisor
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2018
English Abstract
Ferrous sulfate and Folic acid have been widely used for the treatment of iron deficiency such as in anemia or pregnancy.
Because they are ingested by oral they are leading to many of complication, for instance, GI disturbances (constipation, nausea, and unpleasant taste), and dangerously high blood pressure, severe headache, blurred vision and confusion with anxiety if taken as parenteral route.
In the other hand, they are also interacting with numerous drugs, food and minerals).
In this study, four FeSO4 μEm and 8 folic acid μEm systems were developed for transdermal application purpose to overcoming these problems resulted from Oral and parenteral routes.
These W/O μEms are prepared by nonionic surfactants (Span20 & Tween80), IPM as oil phase, and water as aqueous phase.
The μEms for both FeSO4 and Folic acid were characterized for their droplet sizes, zeta potential, pseudo-ternary phase diagram, and rheological properties.
Moreover, the FTIR used to prove the encapsulation of folic acid in the μEm.
The investigation demonstrate that FeSO4 and Folic acid μEms are correspond to the characteristics and properties of the μEm in literature.
In this study, although, the most Microemulsions prepared have ideal characters to the Microemulsions properties written in literature.
The results are shows that a significant variance between droplet size, Zeta potential, rheological properties and characterization of Microemulsions.
The surfactants used in this study shows a factor that may play a role in preparation of those Microemulsions, and also the ratio of these surfactants have an important function to produce an ideal Microemulsion
Main Subjects
Topics
No. of Pages
75
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Methodology.
Chapter Three : Results and discussions.
Conclusion and recommendations
References.
American Psychological Association (APA)
al-Ghatm, Husayn Yusuf Abd Allah. (2018). Developing and characterization of nonionic microemulsions containing ferrous sulfate and folic acid for transdermal application. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832849
Modern Language Association (MLA)
al-Ghatm, Husayn Yusuf Abd Allah. Developing and characterization of nonionic microemulsions containing ferrous sulfate and folic acid for transdermal application. (Master's theses Theses and Dissertations Master). Isra University. (2018).
https://search.emarefa.net/detail/BIM-832849
American Medical Association (AMA)
al-Ghatm, Husayn Yusuf Abd Allah. (2018). Developing and characterization of nonionic microemulsions containing ferrous sulfate and folic acid for transdermal application. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832849
Language
English
Data Type
Arab Theses
Record ID
BIM-832849
