Effects of angiotensin ii antagonist losartan versus angiotensin converting enzyme inhibitor enalapril on serum uric acid levels in patients with metabolic syndrome
Other Title(s)
تأثيرات مثبط الأنجيوتنسين II اللوسلرتان مقابل مثبط الإنزيم المحول للأنجيوتنسين الانالابريل على نستويات الحامض البولي في مصل الدم لدى المرضى الذين يعانون من متلازكة التمثيل الغذائي
Joint Authors
al-Thanoon, Zaynah Abd al-Munim Abd al-Majid
Mahmud, Isam Hammu
Source
Issue
Vol. 6, Issue (sup2) (31 Dec. 2012), pp.126-135, 10 p.
Publisher
University of Duhok College of Medicine
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Background and objectives: To investigate the effects of losartan and enalapril on serum uric acid in hypertensive patients with metabolic syndrome, one hundred and twenty six hypertensive patients, having markers of metabolic syndrome included in the study.
Methods : The patients were divided into two groups.
Group 1 (60 patients) was given losartan (50mg/ day) and group 2 (66 patients) was given enalapril (20 mg/ day).
A control group of seventy apparently healthy individuals were included.
Metabolic syndrome was diagnosed according to diagnostic criteria of metabolic syndrome related to the American National Cholesterol Education Program-Adult Treatment Panel III.
Serum uric acid levels were measured before and after drug administration.
Results: The results revealed a significant higher levels of uric acid were found in the hypertensive patients as compared with control group and a significant drop of uric acid was noted after treatment with losartan but not with enalapril.
Conclusion: In conclusion, this study demonstrates significantly higher serum uric acid concentrations in hypertensive patients having markers of metabolic syndrome.
Losartan but not enalapril therapy produced a significant fall in the serum uric acid level.
Losartan can be useful therapeutic agent to control blood pressure and to reduce serum uric acid level in hypertensive patients having markers of metabolic syndrome and hyperuricaemia.
American Psychological Association (APA)
al-Thanoon, Zaynah Abd al-Munim Abd al-Majid& Mahmud, Isam Hammu. 2012. Effects of angiotensin ii antagonist losartan versus angiotensin converting enzyme inhibitor enalapril on serum uric acid levels in patients with metabolic syndrome. Duhok Medical Journal،Vol. 6, no. (sup2), pp.126-135.
https://search.emarefa.net/detail/BIM-833265
Modern Language Association (MLA)
al-Thanoon, Zaynah Abd al-Munim Abd al-Majid& Mahmud, Isam Hammu. Effects of angiotensin ii antagonist losartan versus angiotensin converting enzyme inhibitor enalapril on serum uric acid levels in patients with metabolic syndrome. Duhok Medical Journal Vol. 6, Second supplement (Dec. 2012), pp.126-135.
https://search.emarefa.net/detail/BIM-833265
American Medical Association (AMA)
al-Thanoon, Zaynah Abd al-Munim Abd al-Majid& Mahmud, Isam Hammu. Effects of angiotensin ii antagonist losartan versus angiotensin converting enzyme inhibitor enalapril on serum uric acid levels in patients with metabolic syndrome. Duhok Medical Journal. 2012. Vol. 6, no. (sup2), pp.126-135.
https://search.emarefa.net/detail/BIM-833265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 131-133
Record ID
BIM-833265