Serum protein pentosidine levels among offspring of individuals with type 2 diabetes mellitus

Abstract EN

Background and objectives: The increase concentrations of serum protein pentosidine in diabetes are generally accepted to be a consequence of hyperglycemia.

Offspring of individuals with type 2 diabetes mellitus are known to have increased risk for hyperglycemia state and metabolic abnormalities .Our aim was to determine serum pentosidine levels in subjects with positive family history of diabetes mellitus in an attempt to investigate its state towards risk of metabolic disease.

Methods: A case-control study design was conducted on 202 apparently healthy subjects (aged 20-40 years).

Among these, 100 subjects (50 sons and 50 daughters) were offspring of individuals with type 2 diabetes mellitus.

The remainders were 51 males and 51 females of comparable age and sex selected from the staff and students of Medical College.

Inclusion criteria were negative family history of diabetes mellitus.

At the baseline, the demographic data was collected, and then a blood sample was taken in fasting state to measure serum pentosidine, glucose, lipid profile and uric acid.

Oral glucose tolerance test was performed.

Insulin levels were measured and homeostatic model assessment-insulin resistance was calculated.

Results: Serum pentosidine levels were significantly higher in the subjects with positive family history of type 2 diabetes mellitus as compared to those with negative family history (serum pentosidine ng/ml, 33.8 Vs 19.4).

There were positive relationship between serum pentosidine and metabolic risk factors.

A highly significant correlation between serum pentosidine and insulin resistance was observed (r=0.557, p<0.001).

Pentosidine determination appear to be a good screening method for risk evaluation of metabolic disease since it presents high specificity (94.1%) and sensitivity (54.0%) values with an area below the ROC curve =0.821,( 95% CI 0.761-0.872).

The positive and negative predictive value was 90 and 67 respectively.

Conclusion: We concluded that determination of serum pentosidine is a good screening method for metabolic risk stratification among offspring of individuals with type 2 diabetes mellitus.