Histopathological study of lung, testis, and urinary bladder of mice treated with 5-fluorouracil
Other Title(s)
دراسة نسجيه مرضية للرئة والخصية والمثانة البولية للفئران المعاملة بعقار 5-Fluorouracil
Joint Authors
al-Jawwali, Najla Kh.
al-Sadi, Hafiz I.
Source
Issue
Vol. 26, Issue 1 (31 Dec. 2017), pp.9-16, 8 p.
Publisher
University of Mosul College of Science
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The histopathological effects of variable intraperitoneal doses of 5-fluorouracil (5-FU) on lung, testis and the urinary bladder of mice were studied.
Following administration of 5- FU according to the dosing schedule used in this study various lesions appeared in the lungs and they included emphysema and thickening of the interalveolar septa due to congestion, hemorrhage and infiltration of mononuclear cells.
In the testes and the urinary bladder, edema of the testicular interstitium, degeneration of the spermatocytes, lack of spermatozoa and hyperplasia of the transitional epithelium of the urinary bladder were seen.
When the dose and time of exposure were increased additional lesions appeared and they included congestion of blood vessels within the testicular interstitium and hyperplasia of the interstitial cells.
Congestion of blood vessels and fibrosis were seen within the submucosa of the urinary bladder, and in the lungs, peribronchiolar lymphoid hyperplasia was evident.
From the results of this study it was concluded that 5-FU in the doses used in this study was associated with histopathological lesions in the lung, testis and urinary bladder of mice.
American Psychological Association (APA)
al-Jawwali, Najla Kh.& al-Sadi, Hafiz I.. 2017. Histopathological study of lung, testis, and urinary bladder of mice treated with 5-fluorouracil. Rafidain Journal of Science،Vol. 26, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-833687
Modern Language Association (MLA)
al-Jawwali, Najla Kh.& al-Sadi, Hafiz I.. Histopathological study of lung, testis, and urinary bladder of mice treated with 5-fluorouracil. Rafidain Journal of Science Vol. 26, no. 1 (2017), pp.9-16.
https://search.emarefa.net/detail/BIM-833687
American Medical Association (AMA)
al-Jawwali, Najla Kh.& al-Sadi, Hafiz I.. Histopathological study of lung, testis, and urinary bladder of mice treated with 5-fluorouracil. Rafidain Journal of Science. 2017. Vol. 26, no. 1, pp.9-16.
https://search.emarefa.net/detail/BIM-833687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 16
Record ID
BIM-833687