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Cloning, expression and purification of trypsin-like protease of the periodontal pathogen tannerella forsythia ATCC 43037
Author
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 29, Issue 6 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Tannerella forsythia, a bacterial species frequently associated with the pathogenesis of periodontal disease and its proteases are implicated as virulence factors, is known to possess trypsin-like activity.
Here, we characterize a trypsin-like protease of T.
forsythia referred to as tlp.
Full length (without a signal peptide) recombinant tlp (102 kDa).
The evidence suggests that the enzyme is a serine protease since it was strongly inhibited by Pefabloc, Tosyl-L-Lysyl-chloromethane hydrochloride (TLCK) and Leupeptin.
The ability to degrade elastin, fibrinogen and the antimicrobial peptide LL-37 may contribute to the pathogenicity of periodontitis.
American Psychological Association (APA)
Karim, Abd al-Karim Y.. 2017. Cloning, expression and purification of trypsin-like protease of the periodontal pathogen tannerella forsythia ATCC 43037. ZANCO Journal of Pure and Applied Sciences،Vol. 29, no. 6, pp.1-9.
https://search.emarefa.net/detail/BIM-833906
Modern Language Association (MLA)
Karim, Abd al-Karim Y.. Cloning, expression and purification of trypsin-like protease of the periodontal pathogen tannerella forsythia ATCC 43037. ZANCO Journal of Pure and Applied Sciences Vol. 29, no. 6 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-833906
American Medical Association (AMA)
Karim, Abd al-Karim Y.. Cloning, expression and purification of trypsin-like protease of the periodontal pathogen tannerella forsythia ATCC 43037. ZANCO Journal of Pure and Applied Sciences. 2017. Vol. 29, no. 6, pp.1-9.
https://search.emarefa.net/detail/BIM-833906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.8-9
Record ID
BIM-833906