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Design, synthesis and antibacterial evaluation of some new pyrazolinyl bromophenylthiazoles
Author
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 29, Issue 6 (31 Dec. 2017), pp.28-37, 10 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
In this study a stepwise reaction has been designed for the synthesis of some new derivatives of Pyrazolinyl bromophenylthiazoles.
The progress started by the benzylation of 2,4-dihydroxyacetophenone to give 1-[2,4- bis(4-chlorobenzyloxy)phenyl]ethanone (1) which was reacted with a number of benzaldehydes to produce a series of new α,β-unsaturated carbonyl compounds (2a-j).
Followed by Michael addition with thiosemicarbazide affording new pyrazolines bearing thiocarbamoyl group(3a-j).
A later derivatives were treated with 4-bromophenacyl-bromide yielding a series of a target pyrazolines having a thiazole linkages(4a-j).The final products were screened for their antimicrobial evaluations using micro broth dilution method against S.aureus as gram positive and E.Coli as gram negative.Spectroscopic techniques were utilized to elucidate the structures of the prepared compounds.
American Psychological Association (APA)
Hawaiz, Faruq E.. 2017. Design, synthesis and antibacterial evaluation of some new pyrazolinyl bromophenylthiazoles. ZANCO Journal of Pure and Applied Sciences،Vol. 29, no. 6, pp.28-37.
https://search.emarefa.net/detail/BIM-833910
Modern Language Association (MLA)
Hawaiz, Faruq E.. Design, synthesis and antibacterial evaluation of some new pyrazolinyl bromophenylthiazoles. ZANCO Journal of Pure and Applied Sciences Vol. 29, no. 6 (2017), pp.28-37.
https://search.emarefa.net/detail/BIM-833910
American Medical Association (AMA)
Hawaiz, Faruq E.. Design, synthesis and antibacterial evaluation of some new pyrazolinyl bromophenylthiazoles. ZANCO Journal of Pure and Applied Sciences. 2017. Vol. 29, no. 6, pp.28-37.
https://search.emarefa.net/detail/BIM-833910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.37
Record ID
BIM-833910