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The biochemical and histological effects of tramadol on liver and kidney of albino mice
Other Title(s)
التأثيرات النسيجية و الكيموحياتية للترامال على الكبد و الكلية في فئران الألبينو
Author
Source
Issue
Vol. 15, Issue 1 (30 Jun. 2018), pp.43-57, 15 p.
Publisher
University of Thi-Qar College of Medicine
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Abstract EN
The aim of this study is to assess the effect of usage of tramadol in liver and kidney in albino mice.
Twenty albino mice were taken (25-30) gm and divided in to two groups, group I (10 mice) which received normal saline intramuscularly and group II (10 mice) which received ) 25 mg /kg body weight ( daily of tramadol intramuscularly for 40 days, the biochemical assay showed significant increase (p value < 0.05) in the Aspartate aminotransferase (AST), alanine aminotransferase (ALT), Urea and Creatinine in experimental group compared to the control group.
The histological examination regarded for liver tissues degenerative changes in the hepatocytes, dilated central vein, focal necrotic area, congested vessel, congested hepatic vein and cytolysis while kidney tissues show widening bowman capsule, interstitial nephritis, necrosis, degenerative change, lymphocyte infiltration in renal interstitial nephritis and degenerative changes in renal proximal tubules.
American Psychological Association (APA)
Muslim, Zahra Zuhayr. 2018. The biochemical and histological effects of tramadol on liver and kidney of albino mice. Thi-Qar Medical Journal،Vol. 15, no. 1, pp.43-57.
https://search.emarefa.net/detail/BIM-834035
Modern Language Association (MLA)
Muslim, Zahra Zuhayr. The biochemical and histological effects of tramadol on liver and kidney of albino mice. Thi-Qar Medical Journal Vol. 15, no. 1 (2018), pp.43-57.
https://search.emarefa.net/detail/BIM-834035
American Medical Association (AMA)
Muslim, Zahra Zuhayr. The biochemical and histological effects of tramadol on liver and kidney of albino mice. Thi-Qar Medical Journal. 2018. Vol. 15, no. 1, pp.43-57.
https://search.emarefa.net/detail/BIM-834035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 54-56
Record ID
BIM-834035