Prevention of preeclampsia using low dose aspirin : s randomised controlled trial

Abstract EN

Objectives: To test the effectiveness of aspirin in low doses to prevention PE in high risk .

Study design: Prospective randomized controlled double blind trial.

Setting: Department of Obstetrics & Gynaecology, Al-Habobi teaching hospital, Thi-qar province/Iraq.

Patients and methods: 100 participants at high risk of developing preeclampsia were randomly divided into 2 groups.

Group I involved 50 pregnant women who received acetyl salicylic acid 75 mg/ day.

Group II included 50 pregnant women who received placebo.

Primary outcomes included gestational hypertension and pre-eclampsia.

Secondary outcomes included development of eclampsia, HELLP syndrome, placental abruption, IUGR, NICU admission, neonatal complications and congenital anomalies.

Results: The incidence of preeclampsia was 22% in the Aspirin group and 44% in the control group (P <0.001).

A highly significant difference was found when comparing the two groups regarding gestational age at delivery (37.8±1.9 vs.

33.2±3.2 ), development of PE (22% vs.

44%) particularly early onset (14% vs.

34%) and severe form (8 vs.

22%) and occurrence of HELLP syndrome (4 vs.

16%) respectively (P <0.001) .

There was a significant difference between cases and controls regarding the development of gestational hypertension (14% VS.

22%) (P 0.05) .There was a significant improvement of neonates delivered to mothers who received aspirin proved by the presence of significant higher birth weight (2989±815 vs.

2062±976), lower occurrence of IUGR (10% vs.

24%), neonatal ICU admission (34% vs.

78%) and respiratory distress syndrome (20% vs.

60%).

Conclusion: the use of low-dose aspirin is of significant importance in reducing the risk of gestational hypertension, pre-eclampsia and IUGR in high risk women.