Spectrophotometric determination of salbutamol Sulphate by coupling with diazotized 5-amino-2-chlorobenzotrifluoride : application to pharmaceutical preparations
Other Title(s)
التقدير الطيفي لكبريتات السالبيوتامول بالاقتران مع الكاشف المؤزوت 5-امينو- 2- كلوروبنزو-ثلاثي فلوريد : تطبيقات في مستحضرات صيدلانية
Joint Authors
Source
Issue
Vol. 25, Issue 3 (31 Dec. 2014), pp.38-49, 12 p.
Publisher
University of Mosul College of Science
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
A simple, rapid and sensitive spectrophotometic method for the estimation of trace amounts of salbutamol sulphate (SBS) in pharmaceutical preparations has been proposed .The method is based on the coupling reaction of the intended compound with diazotized 5-amino-2- chlorobenzotrifluoride in alkaline medium and in the presence of Triton X-100 to form a yelloworange dye that shows maximum absorption at 467 nm.
Beer’s law is obeyed over the range 5 – 300 μg / 10 ml (i.e.,0.5-30 ppm) with a molar absorptivity of 4.20 × 104 l.mol-1.cm-1 and Sandell’s sensitivity index of 0.0139 μg.cm-2, a relative error of +1.08 to +3.46 % and a relative standard deviation of ±0.76 to ±3.50 %, depending on the concentration.
The method has been applied to estimate salbutamol sulphate in syrup, tablet and ventolin.
American Psychological Association (APA)
Uthman, Nabil S.& Asaad, Ali M.. 2014. Spectrophotometric determination of salbutamol Sulphate by coupling with diazotized 5-amino-2-chlorobenzotrifluoride : application to pharmaceutical preparations. Rafidain Journal of Science،Vol. 25, no. 3, pp.38-49.
https://search.emarefa.net/detail/BIM-834193
Modern Language Association (MLA)
Uthman, Nabil S.& Asaad, Ali M.. Spectrophotometric determination of salbutamol Sulphate by coupling with diazotized 5-amino-2-chlorobenzotrifluoride : application to pharmaceutical preparations. Rafidain Journal of Science Vol. 25, no. 3 (2014), pp.38-49.
https://search.emarefa.net/detail/BIM-834193
American Medical Association (AMA)
Uthman, Nabil S.& Asaad, Ali M.. Spectrophotometric determination of salbutamol Sulphate by coupling with diazotized 5-amino-2-chlorobenzotrifluoride : application to pharmaceutical preparations. Rafidain Journal of Science. 2014. Vol. 25, no. 3, pp.38-49.
https://search.emarefa.net/detail/BIM-834193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 48-49
Record ID
BIM-834193