Determination of paracetamol and tramadol hydrochloride in pharmaceutical preparations using green UV method
Other Title(s)
تقدير الباراسيتامول و هيدروكلوريد الترامادول في مستحضراتهما الصيدلانية بطريقة خضراء طيفية
Joint Authors
Dawud, Naghm T.
Mahmud, Hana Sh.
Source
Issue
Vol. 27, Issue 1 (28 Feb. 2018), pp.36-42, 7 p.
Publisher
University of Mosul College of Science
Publication Date
2018-02-28
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
A simple, precise, and friendly environmental method for the determination of paracetamol and tramadol hydrochloride in pharmaceutical preparations has been worked out.
The method is based on the determination of paracetamol at 242 nm and replaces its concentration in a multicomponent system equation for determination of both paracetamol and tramadol at 227 nm.
Beer's law for paracetamol was obeyed over the concentration range 8-25 ppm at 242 nm and 4-16 ppm at 227 nm ,for tramadol it is obeyed over the range 2-14 ppm at 227 nm, water is used as a solvent for dissolution.
The method is applicable to the determination of paracetamol and tramadol in their pharmaceutical preparations without prior separation steps from excipients as well as for determination of paracetamol in the presence of tramadol.
The average recoveries for determination of mentioned drugs were 94.20-100.14 %, and the average relative standard deviation of the method was better than ± 0.646 %.
American Psychological Association (APA)
Mahmud, Hana Sh.& Dawud, Naghm T.. 2018. Determination of paracetamol and tramadol hydrochloride in pharmaceutical preparations using green UV method. Rafidain Journal of Science،Vol. 27, no. 1, pp.36-42.
https://search.emarefa.net/detail/BIM-834576
Modern Language Association (MLA)
Mahmud, Hana Sh.& Dawud, Naghm T.. Determination of paracetamol and tramadol hydrochloride in pharmaceutical preparations using green UV method. Rafidain Journal of Science Vol. 27, no. 1 (2018), pp.36-42.
https://search.emarefa.net/detail/BIM-834576
American Medical Association (AMA)
Mahmud, Hana Sh.& Dawud, Naghm T.. Determination of paracetamol and tramadol hydrochloride in pharmaceutical preparations using green UV method. Rafidain Journal of Science. 2018. Vol. 27, no. 1, pp.36-42.
https://search.emarefa.net/detail/BIM-834576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 42
Record ID
BIM-834576