Study the polymorphism in UCSNP43, 44 to exon 3 of calpain-10 gene of polycystic ovary syndrome women in Thi Qar Povince

Other Title(s)

دراسة تعدد الأشكال UCSNP43,44 للأكسون 3 لمجين Calpain-10 في النساء المصابات بمتلازمة تكيس المبايض في محافظة ذي قار

Joint Authors

al-Ubaydi, Alia Isam Mahmud
Maqtuf, Majidah Ghazi
Jabbar, Inas Abd al-Karim
Yasir, Muhammad Hashim

Source

Journal of Thi-Qar Science

Issue

Vol. 6, Issue 2 (30 Jun. 2017), pp.50-58, 9 p.

Publisher

University of Thi-Qar College of Science

Publication Date

2017-06-30

Country of Publication

Iraq

No. of Pages

9

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Pharmacy, Health & Medical Sciences
Sociology
Diseases

Topics

Abstract EN

The correlation between polycystic ovary syndrome (PCOS) and type-2 diabetes mellitus (T2DM) was reported regarding T2DM genes, which contribute in the pathogenesis of PCOS.

The current study was aimed to investigate the association of CAPN-10 gene UCSNP-43, UCSNP-44 polymorphism with PCOS.

Thirty women with PCOS and 20 healthy, which are matched in their age, were selected to test the anthropometric and biochemical profile of our samples.

Nucleic acid of samples was extracted and genotype analysis was done.

The results of patients-hormonal analysis were indicated that the level of follicle stimulating hormone was low and the levels of other hormones were high in comparison to that of healthy women.

Biomass (BMI) and lipid profiles of PCOS patients were higher than from these in healthy women.

Haplotypes of sequenced samples were determined for each gene fragment.

The same three haplotypes of SNPs-43 were identified in both PCOS and controls samples.

On the other hand, high diversity of haplotypes was found from SNPs-44.

The meta-analysis with fixed and random effects odds ratio (ORs) on the basis of haplotypes frequencies were presented.

American Psychological Association (APA)

Jabbar, Inas Abd al-Karim& al-Ubaydi, Alia Isam Mahmud& Maqtuf, Majidah Ghazi& Yasir, Muhammad Hashim. 2017. Study the polymorphism in UCSNP43, 44 to exon 3 of calpain-10 gene of polycystic ovary syndrome women in Thi Qar Povince. Journal of Thi-Qar Science،Vol. 6, no. 2, pp.50-58.
https://search.emarefa.net/detail/BIM-834625

Modern Language Association (MLA)

Jabbar, Inas Abd al-Karim…[et al.]. Study the polymorphism in UCSNP43, 44 to exon 3 of calpain-10 gene of polycystic ovary syndrome women in Thi Qar Povince. Journal of Thi-Qar Science Vol. 6, no. 2 (Jun. 2017), pp.50-58.
https://search.emarefa.net/detail/BIM-834625

American Medical Association (AMA)

Jabbar, Inas Abd al-Karim& al-Ubaydi, Alia Isam Mahmud& Maqtuf, Majidah Ghazi& Yasir, Muhammad Hashim. Study the polymorphism in UCSNP43, 44 to exon 3 of calpain-10 gene of polycystic ovary syndrome women in Thi Qar Povince. Journal of Thi-Qar Science. 2017. Vol. 6, no. 2, pp.50-58.
https://search.emarefa.net/detail/BIM-834625

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 55-58

Record ID

BIM-834625