Immunohitochemical study of anaplastic lymphoma kinase (ALK) overexpression in non-small cell lung carcinoma (NSCLC) and its clinicopathological correlation
Joint Authors
al-Turayhi, Kaswer
Farhud, Rawa Ghalib
Abd al-Sahib, Rihab Hamid
Source
Issue
Vol. 14, Issue 4 (31 Dec. 2017), pp.649-656, 8 p.
Publisher
University of Babylon College of Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Lung cancer is the most common cancer in men while is third highest incidence among women and is second after breast cancer in mortality.
Most cases occur in older people in age 65 or older, while less than 2% are younger than 45.
The pathogenesis of NSCLC is complex and developed in multistep process in which several gene mutations will occur and coordinate with each other in genotyping and phenotyping outcome.
Non-small cell lung carcinomas (NSCLC) which represent 85% of all lung cancers, it represents the most common type, usually grows and spreads more slowly than other types, histologically is divided into Adenocarcinoma (ADC), Squamous cell carcinoma (SCC) and large cell carcinoma (LCC).
Its incidence and mortality rates vary markedly around the world.
The aim of this study was to assess Anaplastic Lymphoma Kinase (ALK) over expression in Non-small cell lung carcinomas (NSCLC) and its correlation with type, grade and stage of the tumor.
Forty cases of NSCLC was included in this study, collected randomly from the period of February 2016- April 2017 from Al-Harirey Teaching Hospital in Baghdad and Al-Sadder Teaching Hospital in Al-Najaf governate.
The (40) patients (22 male and 18 females) of NSCLC, their median age 58.3 years range from (34-80) years.
A group of 12 cases with benign brain tissue were included as a control group.
A manual Envision procedure was used in the imunohistochemical analysis (Dako Cytomation Copenhagen, Denmark).
ALK over expression was positive in (12.5%) of NSCLC, ALK immunohistochemical staining was more in ADC than SCC and its not correlated with grade and stage of NSCLC.
These finding support the role of ALK in carcinogenesis of ADC and less commonly SCC of the lung.
American Psychological Association (APA)
Farhud, Rawa Ghalib& al-Turayhi, Kaswer& Abd al-Sahib, Rihab Hamid. 2017. Immunohitochemical study of anaplastic lymphoma kinase (ALK) overexpression in non-small cell lung carcinoma (NSCLC) and its clinicopathological correlation. Medical Journal of Babylon،Vol. 14, no. 4, pp.649-656.
https://search.emarefa.net/detail/BIM-835380
Modern Language Association (MLA)
Farhud, Rawa Ghalib…[et al.]. Immunohitochemical study of anaplastic lymphoma kinase (ALK) overexpression in non-small cell lung carcinoma (NSCLC) and its clinicopathological correlation. Medical Journal of Babylon Vol. 14, no. 4 (2017), pp.649-656.
https://search.emarefa.net/detail/BIM-835380
American Medical Association (AMA)
Farhud, Rawa Ghalib& al-Turayhi, Kaswer& Abd al-Sahib, Rihab Hamid. Immunohitochemical study of anaplastic lymphoma kinase (ALK) overexpression in non-small cell lung carcinoma (NSCLC) and its clinicopathological correlation. Medical Journal of Babylon. 2017. Vol. 14, no. 4, pp.649-656.
https://search.emarefa.net/detail/BIM-835380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.654-656
Record ID
BIM-835380