Molecular study of the correlation between hemophilia and the thrombophilic risk factors in Dohuk province by using CVD strip assay
Author
Source
Issue
Vol. 14, Issue 4 (31 Dec. 2017), pp.670-675, 6 p.
Publisher
University of Babylon College of Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Haemophilia A is an X-linked, recessively inherited bleeding disorder which results from deficiency of procoagulant factor VIII (FVIII).
Forty hemophilic patients were enrolled in the current study.
Blood sample were collected and DNA was extracted and subjected to multiplex PCR amplification using specific primers which resulted in bands containing all the suspected mutations associated with hemophilia; CVD Strip Assay was also used to differentiate the obtained mutations.
The results showed that out of the (40) hemophilic individuals, the higher incidence (55%) was for the MTHFR (A1298C) heterozygotic type of mutation while the lower incidence (5%) for a mutation recorded for factor V (G1691A, leiden), factor V (H1299R, R2), prothrombin (G20210A), and facto XIII (V34L).
For the Apo type mutation, B type hasn’t been detected while E type observed in all cases; A1/A2 mutation created the higher incidence with 25% on the other hand, A3/A3 hasn’t been detected and thus it represented 0% of all the Apo mutations.
American Psychological Association (APA)
Hannun, Rana Adil. 2017. Molecular study of the correlation between hemophilia and the thrombophilic risk factors in Dohuk province by using CVD strip assay. Medical Journal of Babylon،Vol. 14, no. 4, pp.670-675.
https://search.emarefa.net/detail/BIM-835390
Modern Language Association (MLA)
Hannun, Rana Adil. Molecular study of the correlation between hemophilia and the thrombophilic risk factors in Dohuk province by using CVD strip assay. Medical Journal of Babylon Vol. 14, no. 4 (2017), pp.670-675.
https://search.emarefa.net/detail/BIM-835390
American Medical Association (AMA)
Hannun, Rana Adil. Molecular study of the correlation between hemophilia and the thrombophilic risk factors in Dohuk province by using CVD strip assay. Medical Journal of Babylon. 2017. Vol. 14, no. 4, pp.670-675.
https://search.emarefa.net/detail/BIM-835390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.674-675
Record ID
BIM-835390