Synthesis, spectral characterization, theoretical, antimicrobial, DNA interaction and in vitro anticancer studies of Cu (II) and Zn (II) complexes with pyrimidine-morpholine based Schiff base ligand
Joint Authors
Sankarganesh, M.
Rajesh, J.
Vinoth Kumar, G. G.
Senthil Kumar, R.
Dhaveethu Raja, J.
Mitu, L.
Source
Journal of Saudi Chemical Society
Issue
Vol. 22, Issue 4 (31 May. 2018), pp.416-426, 11 p.
Publisher
Publication Date
2018-05-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
Novel Cu(II) (1) and Zn(II) (2) complexes with 4-(1-(4-morpholinophenyl)ethylidenea mino)pyrimidine-5-carbonitrile) (L) have been synthesized and characterized by various spectroscopic and analytical techniques.
DFT (density functional theory) studies result confirms that, LMCT mechanism have been done between L and M(II) ions.
The antimicrobial studies indicate that the ligand L and complexes 1 & 2 exhibit higher activity against the E.
coli bacteria and C.
albicans fungi.
The groove binding mode of ligand L and complexes 1 & 2 with CT-DNA have been confirmed by electronic absorption, competitive binding, viscometric and cyclic voltammetric studies.
The electronic absorption titration of ligand L and complexes 1 & 2 with DNA have been carried out in different buffer solutions (pH 4.0, 7.0 & 10.0).
The Kb values of ligand L and complexes 1 & 2 are higher in acidic buffer at pH 4.0 (Kb= 2.42 105, L; 2.8 105, 1; 2.65 105, 2) and the results revealed that, the interaction of synthesized compounds with DNA were higher in the acidic medium than basic and neutral medium.
Furthermore, CT-DNA cleavage studies of ligand L and complexes 1 & 2 have been studied.
The in vitro anticancer activities results show that complexes 1 & 2 have moderate cytotoxicity against cancer cell lines and low toxicity on normal cell line than ligand L..
American Psychological Association (APA)
Sankarganesh, M.& Rajesh, J.& Vinoth Kumar, G. G.& Mitu, L.& Senthil Kumar, R.& Dhaveethu Raja, J.. 2018. Synthesis, spectral characterization, theoretical, antimicrobial, DNA interaction and in vitro anticancer studies of Cu (II) and Zn (II) complexes with pyrimidine-morpholine based Schiff base ligand. Journal of Saudi Chemical Society،Vol. 22, no. 4, pp.416-426.
https://search.emarefa.net/detail/BIM-835394
Modern Language Association (MLA)
Sankarganesh, M.…[et al.]. Synthesis, spectral characterization, theoretical, antimicrobial, DNA interaction and in vitro anticancer studies of Cu (II) and Zn (II) complexes with pyrimidine-morpholine based Schiff base ligand. Journal of Saudi Chemical Society Vol. 22, no. 4 (May. 2018), pp.416-426.
https://search.emarefa.net/detail/BIM-835394
American Medical Association (AMA)
Sankarganesh, M.& Rajesh, J.& Vinoth Kumar, G. G.& Mitu, L.& Senthil Kumar, R.& Dhaveethu Raja, J.. Synthesis, spectral characterization, theoretical, antimicrobial, DNA interaction and in vitro anticancer studies of Cu (II) and Zn (II) complexes with pyrimidine-morpholine based Schiff base ligand. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 4, pp.416-426.
https://search.emarefa.net/detail/BIM-835394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 425-426
Record ID
BIM-835394