![](/images/graphics-bg.png)
The role of β2 antagonist (timolol) and β2 agonist (salbutamol) on cell migration in vitro
Joint Authors
Jawad, Mahmud Jasim
Abu Raghif, Ahmad Rahmah
Ubayd, Hamid Naji
Source
Issue
Vol. 14, Issue 4 (31 Dec. 2017), pp.694-700, 7 p.
Publisher
University of Babylon College of Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Cell migration is a complex and dynamic biological process, it's the movement of the cell from one area to another, generally in response to a chemical signal.
It is an essential feature of living cells for functions such as wound repair, tissue regeneration, cell differentiation, and immune response.
Keratinocytes have the enzymatic machinery to generate catecholamines, they can synthesize endogenous epinephrine, which could be locally secreted into the wound and function in an autocrine manner.
To determine whether beta2-adrenergic receptor (β2AR) antagonist and agonist altered endothelial cells (EC) migration, single-cell migration (SCM) assays were performed with human umbilical vein endothelial cells (HUVEC) in the presence and absence of β2AR agonist and antagonist.
Screening the tested drugs revealed that the salbutamol (β2AR agonist) significantly decreases migration rate on (HUVEC) compared with control group, while timolol (β2AR antagonist) significantly increases the migration rate.
In conclusion the administration of timolol increase single cell migration resulting and enhancement of re-epitheliazation, while administration of salbutamol decrease single cell migration resulting in inhibition of wound re-epitheliazation.
American Psychological Association (APA)
Jawad, Mahmud Jasim& Abu Raghif, Ahmad Rahmah& Ubayd, Hamid Naji. 2017. The role of β2 antagonist (timolol) and β2 agonist (salbutamol) on cell migration in vitro. Medical Journal of Babylon،Vol. 14, no. 4, pp.694-700.
https://search.emarefa.net/detail/BIM-835405
Modern Language Association (MLA)
Jawad, Mahmud Jasim…[et al.]. The role of β2 antagonist (timolol) and β2 agonist (salbutamol) on cell migration in vitro. Medical Journal of Babylon Vol. 14, no. 4 (2017), pp.694-700.
https://search.emarefa.net/detail/BIM-835405
American Medical Association (AMA)
Jawad, Mahmud Jasim& Abu Raghif, Ahmad Rahmah& Ubayd, Hamid Naji. The role of β2 antagonist (timolol) and β2 agonist (salbutamol) on cell migration in vitro. Medical Journal of Babylon. 2017. Vol. 14, no. 4, pp.694-700.
https://search.emarefa.net/detail/BIM-835405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.698-700
Record ID
BIM-835405