Review of the developmental, structural, biochemical, pathophysiological and pharmacological similarities between male and female genitals

Abstract EN

The primary objectives for creation of human spouses are the propagation of race and obtaining peacefulness and pleasure, which are mentioned in AlQuran Alkarim as: Your Lord (Allah) created you from a single person (Adam), and from him (Adam) He created his wife [Hawwa (Eve)], and from them both He created many men and women; … and He created for you spouses that you may find peacefulness and pleasure in them.

To attain these aims, both genders of human beings need some important qualities: Fertility, i.e.

ability to produce enough healthy sperm and ovum, as well as potency and competency to place and transport the sperm and ovum to the proper place for fertilization, development of the embryo and delivery of the baby.

Healthy cavernous tissues in both male and female genitals play an important role in the transference of the sperm to achieve pleasure and contentment during mating.

Despite apparent differences, there are basic similarities between the cavernous tissues of genital organs of both genders.

Important histological features in cavernous tissues in both male and female are the endothelial cells of sinusoids, smooth muscle fibers, fibrous and elastic tissue around sinusoids and the arteries.

Similarly, risk factors like atherosclerosis, hypertension, diabetes and hyperlipidemia cause male and female erectile dysfunction.

Consequently, there are similarities in the pathophysiology and drug management of sex derangements in both genders.

The present article aims to highlight important developmental, structural and biochemical similarities in male and female genitals as well as summarize the pathophysiology and drug treatment of their erectile dysfunctions