Immunoprotection of soluble egg antigens and praziquantel in challenged murine schistosomiasis mansoni
Joint Authors
Abd al-Al, Najla F.
Majdi, Muna
Muhammad, Fatin A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 47, Issue 1 (30 Apr. 2017), pp.1-12, 12 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Control of schistosomiasis would be greatly improved by the development of a vaccine, which could be combined with chemotherapy.
The current study evaluated the potential effect of soluble egg antigens (SEA) associated with or without PZQ in Schistosoma mansoni challenged mice through parasitological, histopathological and serological studies.
Sixty Swiss albino female mice divided into 5 groups (12 mice each); each group was subdivided into 2 groups (6 mice each) according initial and challenged infections.
Mice were sacrificed by rapid decapitation 8 weeks post initial and challenge infections for assessment.
The current results showed marked reduction of egg counts per gram stool, worm burden, granuloma number and size in combined SEA and PZQ group.
Also, significant increase in serum IL-12 & INF-γ, plus marked decrease in serum IL-4 during initial and challenged infections.
The role of PZQ alone was mainly during primary infection and had no role in reinfection, whereas, SEA alone was effective during challenged one.
In conclusion, from the obtained results of the current study the combination of SEA & PZQ was as a possible potent and promising prophylactic treatment for schistosomiasis especially during re-infection in endemic areas.
This prophylactic effect was significantly greater than those observed in the single drug treatment or vaccine used.
American Psychological Association (APA)
Abd al-Al, Najla F.& Muhammad, Fatin A.& Majdi, Muna. 2017. Immunoprotection of soluble egg antigens and praziquantel in challenged murine schistosomiasis mansoni. Journal of the Egyptian Society of Parasitology،Vol. 47, no. 1, pp.1-12.
https://search.emarefa.net/detail/BIM-836035
Modern Language Association (MLA)
Abd al-Al, Najla F.…[et al.]. Immunoprotection of soluble egg antigens and praziquantel in challenged murine schistosomiasis mansoni. Journal of the Egyptian Society of Parasitology Vol. 47, no. 1 (Apr. 2017), pp.1-12.
https://search.emarefa.net/detail/BIM-836035
American Medical Association (AMA)
Abd al-Al, Najla F.& Muhammad, Fatin A.& Majdi, Muna. Immunoprotection of soluble egg antigens and praziquantel in challenged murine schistosomiasis mansoni. Journal of the Egyptian Society of Parasitology. 2017. Vol. 47, no. 1, pp.1-12.
https://search.emarefa.net/detail/BIM-836035
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 11-12
Record ID
BIM-836035