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Histopathological and immunohistochemical studies in experimental heterophyiasis and the role of praziquantel and aminoguanidine
Joint Authors
Taha, Afaf A.
Nada, Suad M. M.
Fathi, Ghadah M.
Abd al-Aziz, Marwah O.
Rashid, Hiyam H.
Muhammad, Fatin A.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 47, Issue 1 (30 Apr. 2017), pp.81-92, 12 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Histopathological diagnosis was used to understand the pathological events associated with Heterophyes heterophyes (H.
heterophyes) infection.
CD3 and CD79α antibodies had been used as markers for both T and B lymphocytes respectively.
Immunohistochemical techniques had several advantages as remarkable sensitivity and specificity.
This study aims to evaluate the roles of praziquantel (PZQ) and aminoguanidine (AG) treatment in H.
heterophyes infected dogs pathologically and immunohistochemically.
Study design included experimental infection of dogs with encysted metacercariae of H.
heterophyes followed by treatment with PZQ and AG.
Tissue samples were taken from small intestinal, liver, heart and lung of all groups for histopathological and immunohistochemical studies.
Pathological changes were detected in infected tissues by histopathological examination.
There was different degree of CD79α+B lymphocytic & CD3+T lymphocytic infiltration detected in immuno-histochemical stained tissues.
PZQ caused improvement of pathological changes in the small intestine.
However the cellular inflammatory infiltration increased.
There was reduction in inflammatory infiltration after intake of AG.
Both PZQ and AG improved the pathological changes in the liver, heart and lung, while the cellular inflammatory infiltration increased after PZQ and reduced by AG.
Moreover in the lung AG improves pulmonary congestion and alveolar wall thickness.
American Psychological Association (APA)
Nada, Suad M. M.& Taha, Afaf A.& Fathi, Ghadah M.& Muhammad, Fatin A.& Abd al-Aziz, Marwah O.& Rashid, Hiyam H.. 2017. Histopathological and immunohistochemical studies in experimental heterophyiasis and the role of praziquantel and aminoguanidine. Journal of the Egyptian Society of Parasitology،Vol. 47, no. 1, pp.81-92.
https://search.emarefa.net/detail/BIM-836046
Modern Language Association (MLA)
Nada, Suad M. M.…[et al.]. Histopathological and immunohistochemical studies in experimental heterophyiasis and the role of praziquantel and aminoguanidine. Journal of the Egyptian Society of Parasitology Vol. 47, no. 1 (Apr. 2017), pp.81-92.
https://search.emarefa.net/detail/BIM-836046
American Medical Association (AMA)
Nada, Suad M. M.& Taha, Afaf A.& Fathi, Ghadah M.& Muhammad, Fatin A.& Abd al-Aziz, Marwah O.& Rashid, Hiyam H.. Histopathological and immunohistochemical studies in experimental heterophyiasis and the role of praziquantel and aminoguanidine. Journal of the Egyptian Society of Parasitology. 2017. Vol. 47, no. 1, pp.81-92.
https://search.emarefa.net/detail/BIM-836046
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 90-92
Record ID
BIM-836046