Twist2 expressions in patients with squamous cell carcinoma of the urinary bladder showed down regulation correlated with good survival and low incidence of distant metastasis
Joint Authors
Kamil, Nura
Wishahi, Muhammad
Khalil, Hibah
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 47, Issue 1 (30 Apr. 2017), pp.101-105, 5 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study evaluated the association between expression of Twist2 monogenic, with pathological features and clinical outcomes of squamous cell carcinoma of the urinary bladder (SCCUB) following radical cystectomy (RC).
Immunohistochemical staining Twist2 was performed on tissue archival samples comprising normal urothelium from ten controls, cystectomy specimens from 87 patients with T2 N0 M0 and T3-4a N0 M0 of bladder squamous cell carcinoma (SCC).all patients with T2-4 SCC undergone radical cystectomy and urinary diversion, follow up was for 5-10 years to assess overall survival (OS) and disease free survival (DFS).
Specimens from 10 muscle-invasive urothelial carcinoma patients were reassessed for Twist2 expression to represent over- expression of Twist2.
All ten controls had normal status of biomarkers which was negative.
Negative or, low, and medium expression of Twist2 was noted in SCC of the urinary bladder of local pathological status with no lymph node metastasis or distant metastasis, clinicopathologic characteristics of the cohort were pT2N0 M0 (n=659 and pT3-4a N0 M0 (n= 22).
Twist2 negative expression was in 36 case, weak expression (n=33), medium expression (n=16), there were no strong expression.
Twist2 low-regulation with combination of tomor stage in SCC of the urinary bladder werel independently associated with overall survival and free disease survival, 7.7 and 5 years survival in pT2 N0 M0(n=65) were 89% and 13% respectively, 7.7 and 5 years survival in pT3-4a N0 M0(n=22) were 72.7% and 22.7% respectively,
American Psychological Association (APA)
Wishahi, Muhammad& Khalil, Hibah& Kamil, Nura. 2017. Twist2 expressions in patients with squamous cell carcinoma of the urinary bladder showed down regulation correlated with good survival and low incidence of distant metastasis. Journal of the Egyptian Society of Parasitology،Vol. 47, no. 1, pp.101-105.
https://search.emarefa.net/detail/BIM-836048
Modern Language Association (MLA)
Wishahi, Muhammad…[et al.]. Twist2 expressions in patients with squamous cell carcinoma of the urinary bladder showed down regulation correlated with good survival and low incidence of distant metastasis. Journal of the Egyptian Society of Parasitology Vol. 47, no. 1 (Apr. 2017), pp.101-105.
https://search.emarefa.net/detail/BIM-836048
American Medical Association (AMA)
Wishahi, Muhammad& Khalil, Hibah& Kamil, Nura. Twist2 expressions in patients with squamous cell carcinoma of the urinary bladder showed down regulation correlated with good survival and low incidence of distant metastasis. Journal of the Egyptian Society of Parasitology. 2017. Vol. 47, no. 1, pp.101-105.
https://search.emarefa.net/detail/BIM-836048
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 104-105
Record ID
BIM-836048