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The association of IL-10 (-592AC) gene polymorphism with progression of type 2 diabetes mellitus in Basrah Province-Iraq
Other Title(s)
علاقة تعدد الإشكال الجيني ل IL-10 (-592AC) بتقدم مرض السكري النوع الثاني في محافظة البصرة العراق
Joint Authors
Shani, Wafa Sadun
Hamid, Saja Majid
Source
Issue
Vol. 59, Issue 2B (30 Jun. 2018), pp.819-826, 8 p.
Publisher
University of Baghdad College of Science
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The study was aimed to investigate the association between IL-10 (-592A / C) gene polymorphism with the progression of type 2 diabeteis mellitus in Basrah Province.
This study included (100) subjects (30) person as a control group and (70) patients with T2DM.
The patients were distributed as two groups according to Their gender and duration of the disease : group for short duration ( ≤ 5 years) and group for long duration( > 5 years).
Lipid profile and glucose concentrations were measured by COBAS analyzer while IL-10 (-592A / C) gene polymorphism was genotyped by using (RFLP-PCR) technique.
CC genotype frequency showed a significant decrease while CA genotype revealed significant increase ( p ≤ 0.05) in T2DM compared with controls .No significant differences were observed in the allelic frequencies between both groups.
Gender and duration of diabetes didn’t show any significant differences.
There is significant association between CA genotype with the risk of T2DM (OR = 1.50, 95 % CI = 1.035-2.173).
We concluded that IL-10 (-592A / C) gene polymorphism contribute in development of T2DM.
American Psychological Association (APA)
Hamid, Saja Majid& Shani, Wafa Sadun. 2018. The association of IL-10 (-592AC) gene polymorphism with progression of type 2 diabetes mellitus in Basrah Province-Iraq. Iraqi Journal of Science،Vol. 59, no. 2B, pp.819-826.
https://search.emarefa.net/detail/BIM-838028
Modern Language Association (MLA)
Hamid, Saja Majid& Shani, Wafa Sadun. The association of IL-10 (-592AC) gene polymorphism with progression of type 2 diabetes mellitus in Basrah Province-Iraq. Iraqi Journal of Science Vol. 59, no. 2B (2018), pp.819-826.
https://search.emarefa.net/detail/BIM-838028
American Medical Association (AMA)
Hamid, Saja Majid& Shani, Wafa Sadun. The association of IL-10 (-592AC) gene polymorphism with progression of type 2 diabetes mellitus in Basrah Province-Iraq. Iraqi Journal of Science. 2018. Vol. 59, no. 2B, pp.819-826.
https://search.emarefa.net/detail/BIM-838028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 824-826
Record ID
BIM-838028