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Metadherin is an apoptotic modulator in prostate cancer through miR-342-3p regulation
Joint Authors
Hu, Kebang
Mu, Xupeng
Kolibaba, Helena
Yin, Qinan
Liu, Chune
Liang, Xueqing
Lu, Ji
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 5 (31 Jul. 2018), pp.975-981, 7 p.
Publisher
Publication Date
2018-07-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Prostate cancer is the second most common cancer in men worldwide.
This study focused to clarify the roles of Metadherin (MTDH) and miR-342-3p in prostate cancer.
We identified that MTDH was upregulated and miR-342-3p was down-regulated in the prostate tissues, and there is an inverse correlation between MTDH and miR-342-3p.
Functional studies revealed that miR-342-3p directly targets MTDH via binding to the 30 untranslated regions (UTRs) in the prostate cancer cells.
Moreover, we also found MTDH overexpression in DU145 and PC3 cells inhibited apoptosis.
Subsequently, miR-342-3p has been revealed to reverse the MTDH effect on the cellular apoptosis in the further studies.
Our results indicate that MTDH repress apoptosis of prostate cancer in vitro and provides a new strategy for human prostate cancer therapy in the future.
American Psychological Association (APA)
Mu, Xupeng& Kolibaba, Helena& Yin, Qinan& Liu, Chune& Liang, Xueqing& Lu, Ji…[et al.]. 2018. Metadherin is an apoptotic modulator in prostate cancer through miR-342-3p regulation. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.975-981.
https://search.emarefa.net/detail/BIM-838441
Modern Language Association (MLA)
Mu, Xupeng…[et al.]. Metadherin is an apoptotic modulator in prostate cancer through miR-342-3p regulation. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.975-981.
https://search.emarefa.net/detail/BIM-838441
American Medical Association (AMA)
Mu, Xupeng& Kolibaba, Helena& Yin, Qinan& Liu, Chune& Liang, Xueqing& Lu, Ji…[et al.]. Metadherin is an apoptotic modulator in prostate cancer through miR-342-3p regulation. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.975-981.
https://search.emarefa.net/detail/BIM-838441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 981
Record ID
BIM-838441