DUSP1 is involved in the progression of small cell carcinoma of the prostate
Joint Authors
Chen, Meng
Liu, Ci
Xiang, Cheng
Zhang, Yan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 5 (31 Jul. 2018), pp.858-862, 5 p.
Publisher
Publication Date
2018-07-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
Small cell carcinoma of the prostate (SCCP) is a rare and the most aggressive variant of prostate cancer.
There is no effective cure or treatment for SCCP.
Therefore, there is an urgent need for new therapy to improve the prognosis of patients with SCCP.
DUSP1 is a dual specific phosphatase with an increasingly recognized in tumor biology.
Altered expression of DUSP1 induced changes in the expression of genes involved in various biological pathways, including cell-cell signaling and angiogenesis.
To understand more about the role of DUSP1 in SCCP, we evaluated the biological function and associated regulatory mechanism of DUSP1.
In this study, DUSP1 was significantly down-regulated in human SCCP compared with the non-carcinoma tissues (P < 0.05).
Overexpression of DUSP1 was found to suppress MAPK signaling and cell proliferation in PC-3 cells.
Additionally, silencing of DUSP1 enhanced MAPK signaling and PC- 3 cell proliferation.
Moreover, it was observed that DUSP1 blocked the phosphorylation of p38 MAPK induced by anisomycin.
Taken together, this investigation suggests that DUSP1 is involved in the progression of SCCP and may provide a new therapeutic target for SCCP treatment.
American Psychological Association (APA)
Zhang, Yajing& Zhang, Yan& Chen, Meng& Liu, Ci& Xiang, Cheng. 2018. DUSP1 is involved in the progression of small cell carcinoma of the prostate. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.858-862.
https://search.emarefa.net/detail/BIM-838472
Modern Language Association (MLA)
Zhang, Yan…[et al.]. DUSP1 is involved in the progression of small cell carcinoma of the prostate. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.858-862.
https://search.emarefa.net/detail/BIM-838472
American Medical Association (AMA)
Zhang, Yajing& Zhang, Yan& Chen, Meng& Liu, Ci& Xiang, Cheng. DUSP1 is involved in the progression of small cell carcinoma of the prostate. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.858-862.
https://search.emarefa.net/detail/BIM-838472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 862
Record ID
BIM-838472