Evaluation of serum soluble urokinase plasminogen activator receptor as a marker for steroid-responsiveness in children with primary nephrotic syndrome
Joint Authors
Musa, Suzan M.
Amin, Maha H.
Ali, Hind Muhammad
Salih, Salah M.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 2 (30 Apr. 2018), pp.290-296, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-04-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Nephrotic syndrome (NS) is the most common primary glomerular disease among children.
It runs a relapsing course involving prolonged periods of treatment with corticosteroids and other immunosuppressive medications.
Soluble urokinase plasminogen activator receptor (suPAR) has been regarded as an inflammatory as well as a permeability factor.
The aim of our study was to evaluate serum suPAR levels in children with NS and its relation to steroid responsiveness.
Our study was carried out on 75 children who were already diagnosed as having NS; they were classified into three groups (steroid sensitive, steroid dependent, and steroid resistant).
Furthermore, 40 apparently healthy children, age and sex matched with the NS patients, were enrolled as controls.
All children had undergone assessment of serum suPAR, renal function tests (urea and creatinine), serum albumin, C-reactive protein, and 24-h protein in urine.
The study found that suPAR level was significantly different between the studied groups (P <0.05), being highest in steroid-resistant NS (66.52 ± 9.7 ng/mL), followed by steroid dependent (56.82 ± 11.09 ng/mL), and steroid-sensitive patients (26.22 ± 3.86 ng/mL), and lowest in the control group (20.29 ± 0.69 ng/mL).
When receiver operating characteristics curves were plotted, suPAR had high sensitivities and specificities in predicting steroid responsiveness, [area under the curve (AUC) = 0.99, 95% confidence interval (CI) = 0.911–1.000, P <0.001], steroid dependence (AUC = 1.00, 95% CI = 0.929–1.000, P <0.001), and predicting steroid resistance.
Our study indicates that suPAR is significantly higher in children with primary NS and varies according to their response to steroid therapy.
It may act as a marker for steroid responsiveness in these children
American Psychological Association (APA)
Musa, Suzan M.& Salih, Salah M.& Ali, Hind Muhammad& Amin, Maha H.. 2018. Evaluation of serum soluble urokinase plasminogen activator receptor as a marker for steroid-responsiveness in children with primary nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 2, pp.290-296.
https://search.emarefa.net/detail/BIM-838510
Modern Language Association (MLA)
Musa, Suzan M.…[et al.]. Evaluation of serum soluble urokinase plasminogen activator receptor as a marker for steroid-responsiveness in children with primary nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 2 (Mar. / Apr. 2018), pp.290-296.
https://search.emarefa.net/detail/BIM-838510
American Medical Association (AMA)
Musa, Suzan M.& Salih, Salah M.& Ali, Hind Muhammad& Amin, Maha H.. Evaluation of serum soluble urokinase plasminogen activator receptor as a marker for steroid-responsiveness in children with primary nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 2, pp.290-296.
https://search.emarefa.net/detail/BIM-838510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 295-296
Record ID
BIM-838510