Impact of body mass index on progression of primary immunoglobulin a nephropathy

Abstract EN

The role of obesity in the progression of primary glomerular diseases is controversial.

A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear.

The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population.

A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study.

We defined two groups of patients according to the BMI value at diagnosis: non-obese group (Group N) with BMI <23 Kg/m2 and the overweight/obese group (Group O) with BMI >23 Kg/m2 as per Asia-Pacific task force criteria.

Baseline characteristics were compared between the groups.

The estimated glomerular filtration rate (eGFR) and urine protein-creatinine ratio (UPCR) were followed up at entry time, 6 months, 12 months, and at the end of follow-up.

Outcomes studied were change in eGFR, proteinuria, and progression to end-stage renal disease.

Statistical analysis was done using the Statistical Package for the Social Sciences version 15.0.

Of 51 patients, 25 (49%) had BMI <23 kg/m2 (Group N) and