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Formulation and evaluation of acyclovir microspheres
Joint Authors
Naresh, K.
Pavani, S.
Mounika, K.
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 1 (30 Jun. 2018), pp.1-7, 7 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
The present study is to formulate and evaluate Acyclovir (ACV) microspheres using natural polymers like chitosan and sodium alginate.
ACV is a DNA polymerase inhibitor used in treating herpes simplex virus infection and zoster varicella infections.
Acyclovir is a suitable candidate for sustained-release (SR) administration as a result of its dosage regimen twice or thrice a day and relatively short plasma half-life (approximately 2 to 4 hours).
Microspheres of ACV were prepared by an ionic dilution method using chitosan and sodium alginate as polymers.
The prepared ACV microspheres were then subjected to FTIR, SEM, particle size, % yield, entrapment efficiency, in vitro dissolution studies and release kinetics mechanism.
The FTIR spectra’s revealed that, there was no interaction between polymer and ACV.
ACV microspheres were spherical in nature, which was confirmed by SEM.
The particle size of microspheres was in the range of 23.8μm to 39.4μm.
72.9% drug entrapment efficiency was obtained in the formulation F3 (1:3 ratio) with a high concentration of calcium chloride (4% w/v).
The in vitro performance of ACV microspheres showed sustained release depending on the polymer concentration and concentration of calcium chloride.
The release data was best fitted with zero order kinetics and Korsemeyer-Peppas release mechanism and diffusion exponent ‘n’ value of was found to be Non-Fickian.
American Psychological Association (APA)
Pavani, S.& Mounika, K.& Naresh, K.. 2018. Formulation and evaluation of acyclovir microspheres. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-838620
Modern Language Association (MLA)
Pavani, S.…[et al.]. Formulation and evaluation of acyclovir microspheres. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 1 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-838620
American Medical Association (AMA)
Pavani, S.& Mounika, K.& Naresh, K.. Formulation and evaluation of acyclovir microspheres. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-838620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7
Record ID
BIM-838620