Investigation of solubility enhancement approach of ticagrelor
Other Title(s)
دراسة وسائل زيادة الذوبان للتيكاكريلور
Joint Authors
Muhammad, Ihsan Ali
Gharib, Muwaffaq Muhammad
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 1 (30 Jun. 2018), pp.8-19, 12 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to increase the solubility and enhancement of dissolution rate of poorly water-soluble drug ticagrelor this was done through formulating and evaluate ticagrelor nanoparticles using solvent antisolvent technology.
Ticagrelor is a practically water-insoluble drug which acts as an antiplatelet medicine.Fifteen formulas were prepared, and different stabilizing agents were used with various concentrations such as poly vinyl pyrrolidine (PVPK-30), poloxamer 188 (PXM) and hydroxypropyl methyl cellulose (HPMC).
The ratios of drug to stabilizers used to prepare the nanoparticles were 1: 0.5, 1:1 and 1:2.
The prepared formulas were evaluated for the sake of particle size, dissolution study, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy.
On the other hand, the increasing dissolution rate as the particle surface area can be increased due to the reduction of particle size to the nano range.The results showed that hydroxy propyl methyl cellulose (HPMC) (F 12) was found to be the best stabilizer.
American Psychological Association (APA)
Muhammad, Ihsan Ali& Gharib, Muwaffaq Muhammad. 2018. Investigation of solubility enhancement approach of ticagrelor. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 1, pp.8-19.
https://search.emarefa.net/detail/BIM-838622
Modern Language Association (MLA)
Muhammad, Ihsan Ali& Gharib, Muwaffaq Muhammad. Investigation of solubility enhancement approach of ticagrelor. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 1 (2018), pp.8-19.
https://search.emarefa.net/detail/BIM-838622
American Medical Association (AMA)
Muhammad, Ihsan Ali& Gharib, Muwaffaq Muhammad. Investigation of solubility enhancement approach of ticagrelor. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 1, pp.8-19.
https://search.emarefa.net/detail/BIM-838622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-19
Record ID
BIM-838622