Dissolution enhancement of raltegravir by hot melt extrusion technique
Author
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 1 (30 Jun. 2018), pp.20-29, 10 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique.
A novel solubility improving agent plasdone s630 was utilized.
The HME raltegravir was formulated into tablet by direct compression method.
The prepared tablets were assessed for all pre and post-compression parameters.
The drug- excipients interaction was examined by FTIR and DSC.
All formulas displayed complying with pharmacopoeial measures.
The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir.
American Psychological Association (APA)
Abd al-Jabbar, Ahmad Sami. 2018. Dissolution enhancement of raltegravir by hot melt extrusion technique. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 1, pp.20-29.
https://search.emarefa.net/detail/BIM-838623
Modern Language Association (MLA)
Abd al-Jabbar, Ahmad Sami. Dissolution enhancement of raltegravir by hot melt extrusion technique. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 1 (2018), pp.20-29.
https://search.emarefa.net/detail/BIM-838623
American Medical Association (AMA)
Abd al-Jabbar, Ahmad Sami. Dissolution enhancement of raltegravir by hot melt extrusion technique. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 1, pp.20-29.
https://search.emarefa.net/detail/BIM-838623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28-29
Record ID
BIM-838623
