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Preparation and characterization of time controlled drug delivery system of sumatriptan using natural polymers
Other Title(s)
تحضير و تقييم نظام تسليم دوائي موقوت لدواء السوماتريبتان باستخدام بوليمر طبيعي
Joint Authors
al-Anbaki, Mina Shihab
Khalil, Yahya Ismail
Rajab, Nawal Ayyash
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 1 (30 Jun. 2018), pp.89-99, 11 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
Time controlled drug delivery systems are designed to release the drug after a predetermined lag time to synchronize the disease circadian rhythm.
Sumatriptan is an effective treatment for acute migraine attacks in which this disease show circadian rhythm between 6 a.m.
and 8 a.m.
The aim of this work is to prepare time-controlled press-coated tablet that was given at bed time to act at early morning with a lag time of 5.45 hours.
Six formulas of fast dissolving core tablets and three formulas of press-coated tablets were prepared by using direct compression method using different variables to prepare core tablets which include: different types and concentrations of superdisintegrants while different concentrations of natural and synthetic polymers were utilized in preparation of press-coated tablets.
The obtained results showed that formula F4 of core tablet, which contained 25 milligrams of sumatriptan, 5% w/w sodium starch glycolate and avicel PH 102 as diluent, was the selected formula that showed the fastest and complete release of sumatriptan.
Also, formula C3 of press-coated tablet , which contained pectin: EC100 mpa.s: HPMCK15M in concentration30 milligrams: 10 milligrams:160 milligrams respectively, was selected as the best coating layer since it gave 5.45 hours lag time .
American Psychological Association (APA)
al-Anbaki, Mina Shihab& Rajab, Nawal Ayyash& Khalil, Yahya Ismail. 2018. Preparation and characterization of time controlled drug delivery system of sumatriptan using natural polymers. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 1, pp.89-99.
https://search.emarefa.net/detail/BIM-838633
Modern Language Association (MLA)
al-Anbaki, Mina Shihab…[et al.]. Preparation and characterization of time controlled drug delivery system of sumatriptan using natural polymers. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 1 (2018), pp.89-99.
https://search.emarefa.net/detail/BIM-838633
American Medical Association (AMA)
al-Anbaki, Mina Shihab& Rajab, Nawal Ayyash& Khalil, Yahya Ismail. Preparation and characterization of time controlled drug delivery system of sumatriptan using natural polymers. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 1, pp.89-99.
https://search.emarefa.net/detail/BIM-838633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 97-99
Record ID
BIM-838633