Synthesis of some novel 4-aminoacetophenone diazenyl and 1, 2, 3-triazole derivatives as potential antibacterial agents
Author
Source
Iraqi National Journal of Chemistry
Issue
Vol. 17, Issue 2 (30 Jun. 2017), pp.117-126, 10 p.
Publisher
University of Babylon College of Sciences
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
With the study of synthesizing new organic compounds and exploring biological potency.
Aryldiazenyl derivatives (2-5) were carried out by coupling of diazonium salt of 4-aminoacetophenone (1) and miscellaneous active methylene compounds such as: acetylacetone, ethyl cyanoacetate, dimedone or methyl acetoacetate.
Moreover substituted 1,2,3-triazole (7-9) were synthesized by the cyclization of 1-(4-azidophenyl) ethanone (6); (which was obtained by coupling of diazonium salt (1) with sodium azid); with acetylacetone, methyl acetoacetate or methyl cyanoacetate, respectively.
The structures of the prepared compounds were promoted by IR, H1NMR and UV/Visible spectra.
Further, they were examined in vetro for antibacterial activity against five strains of bacteria viz., Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Acinetobacter uses the agar diffusion method.
American Psychological Association (APA)
Hassan, Dhifaf F.. 2017. Synthesis of some novel 4-aminoacetophenone diazenyl and 1, 2, 3-triazole derivatives as potential antibacterial agents. Iraqi National Journal of Chemistry،Vol. 17, no. 2, pp.117-126.
https://search.emarefa.net/detail/BIM-838671
Modern Language Association (MLA)
Hassan, Dhifaf F.. Synthesis of some novel 4-aminoacetophenone diazenyl and 1, 2, 3-triazole derivatives as potential antibacterial agents. Iraqi National Journal of Chemistry Vol. 17, no. 2 (2017), pp.117-126.
https://search.emarefa.net/detail/BIM-838671
American Medical Association (AMA)
Hassan, Dhifaf F.. Synthesis of some novel 4-aminoacetophenone diazenyl and 1, 2, 3-triazole derivatives as potential antibacterial agents. Iraqi National Journal of Chemistry. 2017. Vol. 17, no. 2, pp.117-126.
https://search.emarefa.net/detail/BIM-838671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 124-126
Record ID
BIM-838671