Synthesis, identification and antibactrial activity of some new heterocyclic compounds contaning 1, 3, 4-thiadiazole and 1, 3, 4-oxadiazole bearing Schiff base

Abstract EN

1,3,4 -thiadiazole and 1,3,4 –Oxadiazole bearing Schiff bases derivatives were prepared in our study by reacting the 1,3,4 – thiadiazole part with 1,3,4-oxadiazole part in ethanol to produce 1,3,4-oxadiazole hydrazinyl-1,3,4-thiadiazole [C].

which were treated with aromatic aldehyde to produce of 1,3,4- thiadiazole hydrazinyl 1,3,4- oxadiazole bearing Schiff base D1 and D2 ,The structures of synthesized compound D1 and D2 have been identified on the principles of their mass, 1H-NMR,Ft-IR, Mass spectrum and C, H, N elemental analysis .The synthesized compounds C and D1 Which founded have a strong antimicrobial activity, were assessed to their antibacterial activity by inhibition the growth of 3 strains of Gram negative bacteria Pseudomonas auerogenosia , Escherichia coli and one strain which produce enzyme called extended spectrum Beta lactemse (ESBLs) and 2 strains of Gram positive bacteria such as Bacillus cereus and Staphylococcus aureus.

Therefore the chemical compound [C] and [D1] it's an important source of new antimicrobial compounds to treat bacterial