Let-7b contributes to hepatocellular cancer progression through wnt β-catenin signaling
Joint Authors
Wang, Lin
Wang, Yiwei
Mo, Yanbo
Xie, Yuxi
Su, Peng
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 5 (31 Jul. 2018), pp.953-958, 6 p.
Publisher
Publication Date
2018-07-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Elevated evidences show that microRNAs (miRNAs) play vital roles in tumor progression regulation.
However, the functional role of let-7b in hepatocellular carcinoma (HCC) is still largely unknown.
In this study, we try to investigate the biological activity of let-7b in human HCC cells and try to find the potential regulatory signaling pathway.
Our results indicate that let- 7b was remarkably down-regulated in human HCC tissues by qRT-PCR.
In addition, let-7b overexpression decreased the expression of bcatenin and c-Myc, while upregulated E-cadherin expression in HCC cells which was verified by quantitative real-time PCR (qRT-PCR) and western blotting.
Furthermore, Wnt/b-catenin was involved in let-7b biological activity which was revealed by luciferase assay.
Moreover, Wnt/b-catenin signaling inhibitor blocks HCC cell proliferation which is as the same pattern as let-7b overexpression inhibits in HCC cells proliferation.
In conclusion, down-regulated let-7b promotes HCC cell proliferation through Wnt/bcatenin signaling in HCC cells.
These results suggested that appropriate manipulation of let-7b might be a new treatment of human HCC in the future
American Psychological Association (APA)
Wang, Yiwei& Mo, Yanbo& Wang, Lin& Su, Peng& Xie, Yuxi. 2018. Let-7b contributes to hepatocellular cancer progression through wnt β-catenin signaling. Saudi Journal of Biological Sciences،Vol. 25, no. 5, pp.953-958.
https://search.emarefa.net/detail/BIM-838778
Modern Language Association (MLA)
Mo, Yanbo…[et al.]. Let-7b contributes to hepatocellular cancer progression through wnt β-catenin signaling. Saudi Journal of Biological Sciences Vol. 25, no. 5 (Jul. 2018), pp.953-958.
https://search.emarefa.net/detail/BIM-838778
American Medical Association (AMA)
Wang, Yiwei& Mo, Yanbo& Wang, Lin& Su, Peng& Xie, Yuxi. Let-7b contributes to hepatocellular cancer progression through wnt β-catenin signaling. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 5, pp.953-958.
https://search.emarefa.net/detail/BIM-838778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 957-958
Record ID
BIM-838778