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Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus
Joint Authors
al-Daghri, Nasser M.
al-Hazimi, Hazim A.
al-Ajlan, Abd al-Rahman
Masud, Muhammad S.
al-Amr, Abir
al-Nuaymi, Abd Allah M.
al-Attas, Umar S.
al-Aqil, Majid S.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 4 (31 May. 2018), pp.710-714, 5 p.
Publisher
Publication Date
2018-05-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
Spexin (SPX) is a novel biomarker abundantly expressed in several animal and human tissues implicated in food intake and glucose control, respectively.
As new roles for SPX are emerging, the present study explored for the first time, the associations of SPX to several cardiometabolic indices and inflammatory markers in pregnant women, a demographic not yet investigated with respect to SPX.
A total of 117 Saudi women subdivided to those with gestational diabetes mellitus (GDM) (N = 63) and those without (N = 54) were included in this cross-sectional study.
Anthropometry, glycemic, lipid, vitamin D, adipocytokines and inflammatory markers were measured consecutively at baseline and after the 2nd and 3rd trimesters.
Age- and BMI adjusted comparisons revealed that levels of SPX were not significantly different in pregnant women with and without GDM.
In all subjects, circulating levels of SPX showed modest associations with glucose (R = 0.18; p = .08) and HOMA b (R = 0.19; p = .09) as well as significant positive associations with total cholesterol (R = 0.25; p = .02), LDL-cholesterol (R = 0.25; p = .02), 25(OH)D (R = 0.22; p = .04), albumin (R = 0.30; p < .01) and IL1b (R = 0.41; p < .01).
Stepwise regression analysis also suggested that IL1b, leptin and albumin were the significant predictors of SPX.
In summary, SPX levels modestly affect glucose and insulin sensitivity in pregnant women but is not associated with GDM and obesity.
The significant association of SPX to ILb warrants further investigation as to the role of SPX in immune modulation.
American Psychological Association (APA)
al-Daghri, Nasser M.& al-Hazimi, Hazim A.& al-Ajlan, Abd al-Rahman& Masud, Muhammad S.& al-Amr, Abir& al-Ghamidi, Amani Ahmad…[et al.]. 2018. Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus. Saudi Journal of Biological Sciences،Vol. 25, no. 4, pp.710-714.
https://search.emarefa.net/detail/BIM-838794
Modern Language Association (MLA)
al-Ghamidi, Amani Ahmad…[et al.]. Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus. Saudi Journal of Biological Sciences Vol. 25, no. 4 (May. 2018), pp.710-714.
https://search.emarefa.net/detail/BIM-838794
American Medical Association (AMA)
al-Daghri, Nasser M.& al-Hazimi, Hazim A.& al-Ajlan, Abd al-Rahman& Masud, Muhammad S.& al-Amr, Abir& al-Ghamidi, Amani Ahmad…[et al.]. Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 4, pp.710-714.
https://search.emarefa.net/detail/BIM-838794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 714
Record ID
BIM-838794