Correlation between thyroid hormones and anti-TSHR Ab in graves' disease

Abstract EN

Current study we aimed to study the correlation of anti TSH receptor autoantibody with the thyroid hormones in the Graves ' disease patients .

This cross –sectional study includes 60 appearantly healthy control and 60 patients who were early diagnosed with thyrotoxicosis diagnosed as Graves ' disease by the physicians.

Those patients were attended Hormonal Unite at Specialized Center for Endocrinology and Diabetes in Baghdad / Rusafa – Iraq for the period between May- 2016 to January - 2017.

Hormonal estimation including T3, T4 and TSH and immunological study including anti-TSHR antibody.

According to the results, parameters (T4, TSH, anti TSHR) showed no significant difference between male and female (P value were 42.8, 0.26 and 4.17 respectively), thus , sex had no effect on development of disease, no significant differences between (T3 ,T4,TSH) regarding to smoking (p value = 2.066 ,45.78, 0.235 respectively) , but there is significant difference in Anti TSHR between smokers and non-smokers.

there is differences between levels of (T3,T4,TSH and Anti TSHR Ab ) regarding to age groups , in patients age less than 40 years , there is a highly significant difference with T3 ,T4 and Anti TSHR Ab.

There is correlation between Anti-TSHR with T3 and T4 showed highly Significant positive (r= +0.96, +0.75 respectively) , in contrast there is a highly significant negative between Anti-TSHR Ab and TSH (r= -0.66) .

Measurement of Anti TSHR Ab in patients with thyrotoxicosis in a blood can help to establish the diagnosis and sometimes to predict the clinical course and response to treatment.