Evaluation of antioxidants and reactive oxygen species (ROS) levels after combination exposure to chromium (III) and atrazine on liver in wister albion male rats
Author
Source
Iraqi Journal of Biotechnology
Issue
Vol. 17, Issue 1 (31 May. 2018), pp.67-77, 11 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2018-05-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
Atrazine (ATZ)is remaining as one of the most widely broad spectrum pesticide used to control on annual grasses and broadleaf weeds.
While Chromium Cr (III) it has been used currently as food supplemented.
The current study was designed to determine impact of Cr at 7,30 and 300ppm on liver was in absence or in the present of (25 and 50mg/kg) of ATZ for 6 weeks in rats.
Results indicated that deficiency or supplementation with Cr did not cause measurable toxicity and has no obvious effect on oxidative stress or anti-oxidant enzymes and lipid metabolism.
Furthermore, the results showed that the mixture increased level of Aryl Hydrocarbon Receptor (AhR), Reactive Oxygen Species (ROS).
Moreover, the mixture had effects on antioxidants such as super oxide dismutase (SOD), Catalase (CAT), Reduced glutathione (GSH), activity where demonstrated more sever in liver tissue compared to Cr alone, especially as dose of ATZ increased.
Moreover, as dose of Cr in the mixture was increased, the ROS, AhR, CAT, GSH activity was increased compared to low Cr values.
However, SOD activity showed reduction in elevation of mixture concentrations.
The results of this study suggest that there is synergic impact of co-exposure to ATZ and Cr on the parameters used as markers for liver toxicity in the current study.
Further studies are warranted to investigate the interact of Cr and ATZ toxicity in more detail and to avoid having the Cr supplement where ATZ exposure is identified.
American Psychological Association (APA)
Inayah, Sabah H.. 2018. Evaluation of antioxidants and reactive oxygen species (ROS) levels after combination exposure to chromium (III) and atrazine on liver in wister albion male rats. Iraqi Journal of Biotechnology،Vol. 17, no. 1, pp.67-77.
https://search.emarefa.net/detail/BIM-838815
Modern Language Association (MLA)
Inayah, Sabah H.. Evaluation of antioxidants and reactive oxygen species (ROS) levels after combination exposure to chromium (III) and atrazine on liver in wister albion male rats. Iraqi Journal of Biotechnology Vol. 17, no. 1 (May. 2018), pp.67-77.
https://search.emarefa.net/detail/BIM-838815
American Medical Association (AMA)
Inayah, Sabah H.. Evaluation of antioxidants and reactive oxygen species (ROS) levels after combination exposure to chromium (III) and atrazine on liver in wister albion male rats. Iraqi Journal of Biotechnology. 2018. Vol. 17, no. 1, pp.67-77.
https://search.emarefa.net/detail/BIM-838815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 75-77
Record ID
BIM-838815