The present study was performed to investigate the effect of quercetin on nasopharyngeal
Joint Authors
Huang, Dong-Yan
Dai, Zhi-Rao
Li, Wei-Min
Wang, Rong-Guan
Yang, Shi-Ming
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 4 (31 May. 2018), pp.826-831, 6 p.
Publisher
Publication Date
2018-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
The present study was performed to investigate the effect of quercetin on nasopharyngeal carcinoma (NPC) angiogenesis.
The real-time RT-PCR and enzyme-linked immunosorbent assays (ELISA) were performed to analyze the expression levels of vascular endothelial growth factor (VEGF) in nasopharyngeal carcinoma cell lines prior to and after the quercetin treatment.
Effect of quercetin on the rate of cell proliferation was measured by MTT assay.
It was observed that quercetin treatment at a concentration of 10 mg / mL reduced the rate of NPC039 cell viability to 36% compared to control after 24 h.
The expression of VEGF and activity of NF-jB was also markedly reduced.
The ability of tube formation in HUVECs was inhibited significantly on exposure to quercetin compared to the untreated cells.
Therefore, quercetin plays an important role in the inhibition of NPC039 nasopharyngeal carcinoma and can be of therapeutic importance.
American Psychological Association (APA)
Huang, Dong-Yan& Dai, Zhi-Rao& Li, Wei-Min& Wang, Rong-Guan& Yang, Shi-Ming. 2018. The present study was performed to investigate the effect of quercetin on nasopharyngeal. Saudi Journal of Biological Sciences،Vol. 25, no. 4, pp.826-831.
https://search.emarefa.net/detail/BIM-838856
Modern Language Association (MLA)
Huang, Dong-Yan…[et al.]. The present study was performed to investigate the effect of quercetin on nasopharyngeal. Saudi Journal of Biological Sciences Vol. 25, no. 4 (May. 2018), pp.826-831.
https://search.emarefa.net/detail/BIM-838856
American Medical Association (AMA)
Huang, Dong-Yan& Dai, Zhi-Rao& Li, Wei-Min& Wang, Rong-Guan& Yang, Shi-Ming. The present study was performed to investigate the effect of quercetin on nasopharyngeal. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 4, pp.826-831.
https://search.emarefa.net/detail/BIM-838856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 830-831
Record ID
BIM-838856