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Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice
Joint Authors
Lemos, Izabel Cristina Santiago
Bento, Elizangela Beneval
Junior, Francisco Elizaudo de Brito
de Oliveira, Dayanne Rakelly
Fernandes, Cicera Norma
Delmondes, Gyllyandeson de Araujo
Cesario, Francisco Rafael Alves Santana
Rodrigues, Cristina Kelly de Sousa
Sales, Valterlucio dos Santos
de Figueiredo, Francisco Rodolpho Sobreira Dantas Nobrega
Monteiro, Alefe Brito
da Costa, Jose Galberto Martins
Kerntopf, Marta Regina
de Menezes, Irwin Rose Alencar
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 4 (31 May. 2018), pp.609-621, 13 p.
Publisher
Publication Date
2018-05-31
Country of Publication
Saudi Arabia
No. of Pages
13
Main Subjects
Abstract EN
Annona muricata Linnaeus, popularly known as ‘‘graviola” and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent.
The aim of the present study was to validate the gastroprotective activity of the hydroalcoholic extract of the leaves of A.
muricata (HEAM) and to investigate dins (PGEs), ATP-dependent K+ channels and a2-noradrenergic receptors.
HEAM showed significant antiulcer activity against lesions induced by absolute ethanol, acidified ethanol or indomethacin, which was mediated by endogenous gastric prostaglandins.
the underlying mechanisms of action for this effect.
Gastric lesions were induced in mice by absolute ethanol, acidified ethanol or indomethacin.
Before, the animals were pretreated with saline, omeprazole or HEAM orally at doses of 50–400 mg/kg.
To determine the mechanism of action of the extract, we investigated, using specific inhibitors, the involvement of nitric oxide (NO), prostaglan.
American Psychological Association (APA)
Bento, Elizangela Beneval& Junior, Francisco Elizaudo de Brito& Fernandes, Cicera Norma& de Oliveira, Dayanne Rakelly& Cesario, Francisco Rafael Alves Santana& Delmondes, Gyllyandeson de Araujo…[et al.]. 2018. Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. Saudi Journal of Biological Sciences،Vol. 25, no. 4, pp.609-621.
https://search.emarefa.net/detail/BIM-838870
Modern Language Association (MLA)
Bento, Elizangela Beneval…[et al.]. Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. Saudi Journal of Biological Sciences Vol. 25, no. 4 (May. 2018), pp.609-621.
https://search.emarefa.net/detail/BIM-838870
American Medical Association (AMA)
Bento, Elizangela Beneval& Junior, Francisco Elizaudo de Brito& Fernandes, Cicera Norma& de Oliveira, Dayanne Rakelly& Cesario, Francisco Rafael Alves Santana& Delmondes, Gyllyandeson de Araujo…[et al.]. Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 4, pp.609-621.
https://search.emarefa.net/detail/BIM-838870
Data Type
Journal Articles
Language
English
Record ID
BIM-838870