Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats
Joint Authors
Khuzai, Majid
Beheshti, Farimah
Norouzi, Fatimah
Abareshi, Azam
Alikhani, Vajiheh
Musawi, Sawsan
Biglari, Ghazzali
Husayni, Mahmud
Soukhtanloo, Muhammad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 3 (30 Jun. 2018), pp.554-566, 13 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-06-30
Country of Publication
Saudi Arabia
No. of Pages
13
Main Subjects
Abstract EN
Liver and renal dysfunction accompanying with the tissues’ oxidative damage has been reported to occur during Inflammation.
Nigella sativa has been well known for its antioxidant and anti-inflammatory effects.
The aim of this study was to investigate preventive effects of N.
sativa on liver and renal tissue damage in lipopolysaccharide (LPS)-treated rats.
The rats were divided into five groups: (1) control; (2) LPS (1 mg/kg, IP, for 10 days), (3–5) N.
sativa hydroethanolic extract (100, 200, or 400 mg/kg) before LPS.
Compared to LPS group, treatment by the extract decreased malondialdehyde, nitric oxide (NO) metabolites, and interleukin-6 while increased thiol content and superoxide dismutase and catalase activities in both renal and liver tissues.
N.
sativa extract also decreased serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase concentration, while it increased serum protein and albumin compared with LPS group.
In LPS group, serum blood urea nitrogen and creatinine were higher than control group.
The extract reversed the negative effects of LPS.
The results demonstrated that the N.
sativa prevented liver and renal tissue damage in LPS-treated rats.
It is suggested that the effects are due to its antioxidant and anti-inflammatory effects.
American Psychological Association (APA)
Beheshti, Farimah& Norouzi, Fatimah& Abareshi, Azam& Khuzai, Majid& Alikhani, Vajiheh& Musawi, Sawsan…[et al.]. 2018. Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 3, pp.554-566.
https://search.emarefa.net/detail/BIM-839161
Modern Language Association (MLA)
Beheshti, Farimah…[et al.]. Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 3 (Jun. 2018), pp.554-566.
https://search.emarefa.net/detail/BIM-839161
American Medical Association (AMA)
Beheshti, Farimah& Norouzi, Fatimah& Abareshi, Azam& Khuzai, Majid& Alikhani, Vajiheh& Musawi, Sawsan…[et al.]. Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 3, pp.554-566.
https://search.emarefa.net/detail/BIM-839161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 564-566
Record ID
BIM-839161