Pulmonary function tests and plasma nitric oxide levels in pediatric hemodialysis

Joint Authors

Shukri, Dina Muhammad
al-Bihidi, Rabab Muhammad
Khidr, Mahmud Khidr Muhammad
Yusuf, Dua Muhammad

Source

Saudi Journal of Kidney Diseases and Transplantation

Issue

Vol. 29, Issue 3 (30 Jun. 2018), pp.578-585, 8 p.

Publisher

Saudi Center for Organ Transplantation

Publication Date

2018-06-30

Country of Publication

Saudi Arabia

No. of Pages

8

Main Subjects

Medicine

Abstract EN

The relationships between the lungs and the kidneys are clinically important; however, the impact of nitric oxide (NO) on respiratory function in renal patients is less known.

The aim of this study is to evaluate pulmonary function tests (PFTs), NO level and their correlation in children on treatment with hemodialysis (HD) for the end-stage renal disease.

This study was performed among 20 patients on regular HD and 20 controls.

Participants were subjected to clinical examination, and pulmonary function evaluation was performed using spirometry.

The following parameters were obtained as follows: forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), Tüffenau index (FEV1/%FVC), (FEF25%–75%), and peak expiratory flow.

Spirometry was carried out before and after HD sessions, and at the same time of clinical assessments, blood samples were taken to measure arterial-blood gas (ABG) and NO levels.

There was the statistically significant difference between patient and control groups regarding NO and all PFTs except FEV1/FVC.

There was no statistically significant correlation between NO and biological parameters in both cases and controls, but there was negative although the statistically not significant correlation between the PFTs, ABG, and duration of dialysis in the case group.

There was statistically significant negative correlation between NO and some PFTs in case group; also the effect of dialysis on pulmonary functions tests and NO levels were only on the FVC of patients which significantly improved.

Postdialysis blood gases remained normal among children on HD.

NO may be involved in the deterioration of pulmonary function, and therefore, we feel that it can be used as a marker of clinical deterioration.

American Psychological Association (APA)

Yusuf, Dua Muhammad& Shukri, Dina Muhammad& al-Bihidi, Rabab Muhammad& Khidr, Mahmud Khidr Muhammad. 2018. Pulmonary function tests and plasma nitric oxide levels in pediatric hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 3, pp.578-585.
https://search.emarefa.net/detail/BIM-839167

Modern Language Association (MLA)

Yusuf, Dua Muhammad…[et al.]. Pulmonary function tests and plasma nitric oxide levels in pediatric hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 3 (Jun. 2018), pp.578-585.
https://search.emarefa.net/detail/BIM-839167

American Medical Association (AMA)

Yusuf, Dua Muhammad& Shukri, Dina Muhammad& al-Bihidi, Rabab Muhammad& Khidr, Mahmud Khidr Muhammad. Pulmonary function tests and plasma nitric oxide levels in pediatric hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 3, pp.578-585.
https://search.emarefa.net/detail/BIM-839167

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 584-585

Record ID

BIM-839167